Développement de sources supercontinuum et applications biomédicales
Multivariate curve resolution with autoencoders for CARS microspectroscopy
Coherent anti-Stokes Raman scattering (CARS) microspectroscopy is a powerful tool for label-free cell imaging thanks to its ability to acquire a rich amount of information. An important family of operations applied to such data is multivariate curve resolution (MCR). It aims to find main components of a dataset and compute their spectra and concent...
La microspectroscopie CARS appliquée au suivi de l'activation d'un récepteur associé à la cancérogenèse
Parmi les technologies d’analyses d’échantillons biologiques sans marquage préalable, la microspectroscopie vibrationnelle est en plein essor. Grâce à la vibration des liaisons entre atomes, elle permet de localiser dans la cellule des biomolécules (protéines, acides nucléiques, lipides) associées à des organites. Mon étude a consisté à utiliser la...
Linear and nonlinear Raman microspectroscopy: History, instrumentation, and applications
Published in Optical Review
Through carrying out Raman spectroscopy under a microscope, we can observe the molecular distribution and dynamics of living cells in situ without staining or labeling. In general, Raman microscopy/microspectroscopy is classified into spontaneous Raman microscopy/microspectroscopy and nonlinear Raman microscopy/microspectroscopy. This review will f...
