Rose, Jacqueline K. Butterfield, Michael Liang, Joseph Parvand, Mahraz Lin, Conny H. S. Rankin, Catharine H.
Published in
Frontiers in Behavioral Neuroscience
Exposure to alcohol causes deficits in long-term memory formation across species. Using a long-term habituation memory assay in Caenorhabditis elegans, the effects of ethanol on long-term memory (> 24 h) for habituation were investigated. An impairment in long-term memory was observed when animals were trained in the presence of ethanol. Cues of in...
Aprison, Erin Z Dzitoyeva, Svetlana Angeles-Albores, David Ruvinsky, Ilya
Published in
Proceedings of the National Academy of Sciences of the United States of America
Pheromones exchanged by conspecifics are a major class of chemical signals that can alter behavior, physiology, and development. In particular, males and females communicate with potential mating partners via sex pheromones to promote reproductive success. Physiological and developmental mechanisms by which pheromones facilitate progeny production ...
sitia;, giovanni
Food-grade titanium dioxide (E171) contains variable percentages of titanium dioxide (TiO2) nanoparticles (NPs), posing concerns for its potential effects on human and animal health. Despite many studies, the actual relationship between the physicochemical properties of E171 NPs and their interaction with biological targets is still far from clear....
Harris-Gauthier, Namastheé Traa, Annika AlOkda, Abdelrahman Moldakozhayev, Alibek Anglas, Ulrich Soo, Sonja K. Van Raamsdonk, Jeremy M.
Published in
Redox Biology
• Mitochondrial thioredoxin system genes are specifically upregulated in long-lived mitochondrial mutants. • Upregulation of mitochondrial thioredoxin genes is mediated by mitochondrial unfolded protein response. • Mitochondria thioredoxin genes contribute to lifespan extension in long-lived mitochondrial mutants. • Mitochondrial thioredoxin genes ...
Zárate-Potes, Alejandra Ali, Irtiqa Ribeiro Camacho, Margarida Brownless, Hayley Benedetto, Alexandre
Published in
Frontiers in Microbiology
Graphical abstract of the approach employed in this study. Combined analyses of C. elegans-microbe transcriptomics (1) and gene tissue expression maps (2), with high-throughput stress and infection assays following host-gene inactivation (3), can guide predictions and accelerate identification of genetic interactions involved in nematode-microbe in...
Kim, Dongyoung Kim, Byunghyuk
Published in
Frontiers in Neuroanatomy
Studies on sexual dimorphism in the structure and function of the nervous system have been pivotal to understanding sex differences in behavior. Such studies, especially on invertebrates, have shown the importance of neurons specific to one sex (sex-specific neurons) in shaping sexually dimorphic neural circuits. Nevertheless, recent studies using ...
Bao, Keting Liu, Wenwen Song, Zhouzhi Feng, Jiali Mao, Zhifan Bao, Lingyuan Sun, Tianyue Hu, Zelan Li, Jian
Published in
eLife
While screening our in-house 1072 marketed drugs for their ability to extend the lifespan using Caenorhabditis elegans ( C. elegans ) as an animal model, crotamiton ( N -ethyl-o-crotonotoluidide) showed anti-aging activity and was selected for further structural optimization. After replacing the ortho-methyl of crotamiton with ortho-fluoro, crotami...
Dridi, Haikel Forrester, Frances Umanskaya, Alisa Xie, Wenjun Reiken, Steven Lacampagne, Alain Marks, Andrew
Published in
eLife
Age-dependent loss of body wall muscle function and impaired locomotion occur within 2 weeks in Caenorhabditis elegans (C. elegans); however, the underlying mechanism has not been fully elucidated. In humans, age-dependent loss of muscle function occurs at about 80 years of age and has been linked to dysfunction of ryanodine receptor (RyR)/intracel...
Kalia, Vrinda Niedzwiecki, Megan M Bradner, Joshua M Lau, Fion K Anderson, Faith L Bucher, Meghan L Manz, Katherine E Schlotter, Alexa Puri Fuentes, Zoe Coates Pennell, Kurt D
...
Published in
PNAS nexus
Exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) has been associated with increased risk of Alzheimer's disease (AD), a disease also associated with hyperphosphorylated tau (p-tau) protein aggregation. We investigated whether exposure to DDT can exacerbate tau protein toxicity in Caenorhabditiselegans using a transgenic strain that e...
Wan, Jason
Aging is a complex, universal process that impacts us all differently. An increasingly important aspect of aging research is studying gene expression and regulation. Gene expression is age-, tissue-, and individual-dependent so it is important to capture all these pieces of information. While there are pooled-sample techniques that can measure the ...
