Identification of Women at High Risk of Breast Cancer Who Need Supplemental Screening.
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Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk.
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Mammographic density (MD) phenotypes are strongly associated with breast cancer risk and highly heritable. In this GWAS meta-analysis of 24,192 women, we identify 31 MD loci at P
Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells.
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Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, the immunosuppressive factors induced by radiation on tumor cells remain to be identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast cancer (BC) cells and RT-treated mouse syngeneic B...
Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, p...
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Background Circulating tumour DNA (ctDNA) testing might provide a current assessment of the genomic profile of advanced cancer, without the need to repeat tumour biopsy. We aimed to assess the accuracy of ctDNA testing in advanced breast cancer and the ability of ctDNA testing to select patients for mutation-directed therapy. Methods We did an open...
Nomogram for Predicting Breast Cancer-Specific Mortality of Elderly Women with Breast Cancer
Published in Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background The objectives of this study were to evaluate the cumulative incidence of breast cancer-specific death (BCSD) and other cause-specific death in elderly patients with breast cancer (BC) and to develop an individualized nomogram for estimating BCSD. Material/Methods Data were retrieved from the Surveillance, Epidemiology, and End Results p...
Diffuse Intrasinusoidal Hepatic Metastasis from Breast Cancer Presenting as Liver Failure: Effective and Rapid Treatment...
Published in The American Journal of Case Reports
Patient: Female, 28-year-old Final Diagnosis: Hepatic metastasis • metastatic breast cancer • sinusoidal occlusive syndrome Symptoms: Abdominal distension • abdominal pain • lower extremity edema • nausea • vomiting Medication:— Clinical Procedure: — Specialty: General and Internal Medicine • Oncology Objective: Challenging differential diagnosis B...
Trajectory and uniqueness of mutational signatures in yeast mutators.
The acquisition of mutations plays critical roles in adaptation, evolution, senescence and tumorigenesis. Massive genome sequencing has allowed extraction of specific features of many mutational landscapes but it remains difficult to retrospectively determine the mechanistic origin(s), selective forces and trajectories of transient or persistent mu...
Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer
Published in Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Mini-chromosome maintenance families (MCMs) were considered the key factors for DNA replication initiation. Emerging evidences indicate that MCM2-7 (MCMs) are highly expressed in tissues from various malignant tumors. However, little is known about the clinical values of MCMs in breast cancer. Material/Methods In our study, a comprehensi...
Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of...
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BackgroundCombined targeting of CDK4/6 and ER is now the standard of care for patients with advanced ER+/HER2- breast cancer. However, acquired resistance to these therapies frequently leads to disease progression. As such, it is critical to identify the mechanisms by which resistance to CDK4/6-based therapies is acquired and also identify therapeu...
Early Death Incidence and Prediction in Stage IV Breast Cancer
...Published in Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background The early death of patients is a global cancer issue. We aimed to identify the risk factors for early death in stage IV breast cancer. Predictive nomograms for early death evaluation were generated based on the risk factors. Material/Methods Based on the Surveillance, Epidemiology, and End Results (SEER) database, patients diagnosed with...
