Menni, Cristina Kiddle, Steven J Mangino, Massimo Viñuela, Ana Psatha, Maria Steves, Claire Sattlecker, Martina Buil, Alfonso Newhouse, Stephen Nelson, Sally
...
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent individuals from the AddNeuroMed, Alzheimer's Research UK, and Dementia Case Registry cohorts. Results were further validated using...
Dolan, Lianne B. Campbell, Kristin Gelmon, Karen Neil-Sztramko, Sarah Holmes, Daniel McKenzie, Donald C.
Published in
Supportive Care in Cancer
BackgroundExercise therapy is being explored in a variety of cancer populations to counteract treatment-related deconditioning. Higher intensity interval protocols are being prescribed to improve physical function and attenuate surrogates of comorbidity in non-cancer populations. The purpose of this study is to explore the safety of higher intensit...
Schmalbach, Barbara Stepanow, Olga Jochens, Arne Riedel, Christian Deuschl, Günther Kuhlenbäumer, Gregor
Published in
Cerebrovascular Diseases
Background: Platelet-leukocyte aggregation (PLA) and platelet activation are found to be on the higher side in ischemic stroke patients. The correlation of PLA with clinical features has not been intensively investigated and the influence of genetic factors on PLA is still unexplored. The interaction of platelets with leukocytes is mainly determine...
de Jesus, Jemmyson Romário de Campos, Bruna Kauely Galazzi, Rodrigo Moretto Martinez, José Luis Capelo Arruda, Marco Aurélio Zezzi
Published in
Analytical and Bioanalytical Chemistry
In this manuscript we briefly describe bipolar disorder (a depressive and manic mental disease), its classification, its effects on the patient, which sometimes include suicidal tendencies, and the drugs used for treatment. We also address the status quo with regard to diagnosis of bipolar disorder and recent advances in bioanalytical approaches fo...
Kutz, Alexander Grolimund, Eva Christ-Crain, Mirjam Thomann, Robert Falconnier, Claudine Hoess, Claus Henzen, Christoph Zimmerli, Werner Mueller, Beat Schuetz, Philipp
...
Published in
BMC Anesthesiology
BackgroundBlood biomarkers are increasingly used to diagnose, guide therapy in, and risk-stratify community-acquired pneumonia (CAP) patients in emergency departments (EDs). How pre-analytic factors affect these markers’ initial levels in this population is unknown.MethodsIn this secondary analysis of consecutive ED patients with CAP from a large m...
Sattlecker, Martina Kiddle, Steven Newhouse, Stephen Proitsi, Petroula Nelson, Sally Williams, Stephen Johnston, Caroline Killick, Richard Simmons, Andrew Westman, Eric
...
Published in
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
BackgroundBlood proteins and their complexes have become the focus of a great deal of interest in the context of their potential as biomarkers of Alzheimer's disease (AD). In this work, we assessed the largest number of plasma proteins to date, in a single study, for their utility as biomarkers of seven AD relevant outcome measures. MethodsA SOMAsc...
Vaz, Simone Gutman Mesquita, Rebeca Menelau Almeida, Telga Lucena Alves Craveiro Teixeira, Miriam Nogueira Manso, Helena Emília Cavalcanti Cordeiro... Manso Filho, Hélio Cordeiro
Published in
Comparative Clinical Pathology
The goal of this study is to characterize the variations in glutamine (GLN) concentration and other blood biomarkers in dogs after blood donation. Blood samples were collected from 12 dogs that were used regularly for blood donation. The procedure was performed on the following occasions: before blood donation and +24 h, +7 days, +15 days, and +30 ...
Buijsen, Jeroen van Stiphout, Ruud G. Menheere, Paul P.C.A. Lammering, Guido Lambin, Philippe
Published in
Radiotherapy and Oncology
Purpose/objectiveChemoradiation (CRT) has been shown to lead to downsizing in an important part of rectal cancers. In order to tailor treatment at an earlier stage during treatment, predictive models are being developed. Adding blood biomarkers may be attractive for prediction, as they can be collected very easily and determined with excellent repr...
Maffei, Francesca Angelini, Sabrina Cantelli Forti, Giorgio Hrelia, Patrizia
Published in
Current Colorectal Cancer Reports
Colorectal cancer (CRC) is currently the third most common malignancy in the world. The prognosis of CRC is directly related to the stage of the cancer at the time of diagnosis, and survival is significantly better when CRC is diagnosed at an early stage. Consequently, there is an urgent need for the discovery of non-invasive diagnostic markers tha...
Chew, W.-S. Poh, K.-W. Siddiqi, N.J. Alhomida, A.S. Yu, L.E. Ong, W.-Y.
10.3109/1354750X.2012.727030 / Biomarkers / 17 / 8 / 750-757 / BIOMF
