Při kultivaci buněk v bioreaktoru za dynamických podmínek dochází k lepším výsledkům než za statických. Řízená perfuze kultivačního media může být realizována peristaltickou pumpou. Takovéto řešení vytváří nekontrolovatelné rázové vlny, které jsou nežádoucí při kultivaci tubulární tkáně. Proto bylo zvoleno řešení pomocí vzduchového tlakového řízení...
Published in Probiotics and antimicrobial proteins
Today, the enhancement of spore yields of Bacillus subtilis has considerable interest and has been widely investigated. In this context, studies have been carried out to improve the spore yield as well as the production amount. In order to perform this, optimization studies are conducted for large-scale production of B. subtilis in bioreactors. The...
Published in Biomaterials advances
Tissue engineering (TE) is the study and development of biological substitutes to restore, maintain or improve tissue function. Tissue engineered constructs (TECs) still present differences in mechanical and biological properties compared to native tissue. Mechanotransduction is the process through which mechanical stimulation triggers proliferatio...
In recent years, biotechnological processes have gained increased interest due to their potential for high-value compound production and waste recycling. This shift towards biotechnology is driven by global challenges such as food security, climate change, and the transition to renewable resources. To address the limitations of large-scale fermenta...
The study of microorganisms in communities is important for the understanding of their metabolism and their association with human disease, but also for a range of biotechnological applications, since microbial consortia can be used to increase the production of relevant compounds. Our group previously developed a coarse-grained mathematical model ...
Published in Clinical and experimental otorhinolaryngology
Using tissue-engineered materials for esophageal reconstruction is a technically challenging task in animals that requires bioreactor training to enhance cellular reactivity. There have been many attempts at esophageal tissue engineering, but the success rate has been limited due to difficulty in initial epithelialization in the special environment...
Published in Frontiers in Plant Science
Plant micropropagation has been adapted in the fields of agriculture, horticulture, forestry, and other related fields for large-scale production of elite plants. The use of liquid media and adoption of bioreactors have escalated the production of healthy plants. Several liquid-phase, gas-phase, temporary immersion, and other modified bioreactors h...
Published in Heliyon
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Published in Archives of microbiology
Concerning the potential application of the optically active isomer (R,R)-2,3-butanediol, and its production by a non-pathogenic bacterium Paenibacillus polymyxa ATCC 842, the present study evaluated the use of a commercial crude yeast extract Nucel®, as an organic nitrogen and vitamin source, at different medium composition and two airflows (0.2 o...
Published in Pharmaceutical research
There is a growing interest in extracellular vesicles (EVs) for ocular applications as therapeutics, biomarkers, and drug delivery vehicles. EVs secreted from mesenchymal stem cells (MSCs) have shown to provide therapeutic benefits in ocular conditions. However, very little is known about the properties of bioreactor cultured-3D human retinal organ...
