Regulatory T (Treg) cells are a subset of adaptive immune cells known for their immunosuppressive functions. Emerging evidence demonstrates that Treg exist throughout the body in tissue-specific sub-populations with specialized functions. RNA-seq analysis performed on mice during systemic autoimmune inflammation revealed high expression levels of N...
While parasites can alter community structure, comprise a substantial proportion of the diversity in food webs, and also help us resolve trophic links, few studies have incorporated parasites into food webs. One of the main challenges of adequately adding parasites in food webs is accurate identification of parasites to the species level. In additi...
Organic anion transporter 1 (OAT1) and 3 (OAT3) are multi-specific renal drug transporters that facilitate the uptake and clearance of a wide range of endogenous and exogenous molecules. While they’ve been extensively studied for their clinical role in drug disposition and potential drug-drug interactions (DDIs), their physiological role in regulat...
Myeloproliferative Neoplasms are a collection of blood cancers in which there is a dysregulation of hematopoiesis leading to an over proliferation of myeloid cells. These are often caused by activating mutations in non-receptor tyrosine kinases. Recently, mutations in the C terminus of calreticulin have been discovered in MPN patients.Our lab has c...
Mating and reproducing are key elements of fitness. Decisions made (consciously or not) during mating and reproducing have costs and benefits which may vary as a function of the contexts in which the decisions are made. In this dissertation, I explore associations between variation in two contextual factors (the social environment and the phenotypi...
he Project Based Learning (PBL) teaching methodology is an active, student-centred working method in which the teaching staf takes on the role of facilitator-guidance-tutor. he general objective of this study is to analyze the success of the PBL methodology in the subject of Writing and Execution of Projects in the Biology Degree. For this purpose,...
Misregulated proteolysis has been linked to the initiation and progression of a large number of pathological processes. Transcriptional analysis of primary tumors and cell lines in breast cancer identified differential expression of proteases and protease inhibitors associated with different molecular subtypes. However, due to the tight regulation ...
Many mammalian species display sex differences in the frequency of play behavior, particularly in the domain of social play. Yet the animal literature largely lacks longitudinal studies on developmental patterns of play over the lifespan, which are important for understanding the timing of sex differences and the evolutionary functions of this ubiq...
As the rate of Type II Diabetes Mellitus (T2DM) develops not only in adults but in youth, many other health related problems are starting to arise in association. A major complication related to T2DM is cardiovascular disease, which female diabetic patients have been found to have a worsened outcome compared to male diabetic patients. To get a bett...
Depuis quelques années, de nombreux travaux de recherche en biologie révèlent que la coopération est un principe important de la construction du monde vivant. Dans l’histoire de l’évolution, la coopération et notamment la symbiose microbienne ont été une source infinie d’innovations. Dans chacune des espèces, les groupes les plus coopératifs sont c...
