Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic ne...
10.26508/lsa.202201385 / LIFE SCIENCE ALLIANCE / 5 / 8 / completed / completed
Fluorescence Imaging of 3D Cell Models with Subcellular Resolution
Over the past years, research has made impressive breakthroughs towards the development and implementation of 3D cell models for a wide range of applications, such as drug development and testing, organogenesis, cancer biology, and personalized medicine. Opposed to 2D cell monolayer culture systems, advanced 3D cell models better represent the in v...
Pan-Africanism vs. single-origin of Homo sapiens: Putting the debate in the light of evolutionary biology
The scenario of Homo sapiens origin/s within Africa has become increasingly complex, with a pan-African perspective currently challenging the long-established single-origin hypothesis. In this paper, we review the lines of evidence employed in support of each model, highlighting inferential limitations and possible terminological misunderstandings....
Mathematical relationships between spinal motoneuron properties
Our understanding of the behaviour of spinal alpha-motoneurons (MNs) in mammals partly relies on our knowledge of the relationships between MN membrane properties, such as MN size, resistance, rheobase, capacitance, time constant, axonal conduction velocity and afterhyperpolarization period. We reprocessed the data from 40 experimental studies in a...
Pathogenesis of distal symmetrical polyneuropathy in diabetes
Distal symmetrical polyneuropathy (DSPN) is a serious complication of diabetes associated with significant disability and mortality. Although more than 50% of people with diabetes develop DSPN, its pathogenesis is still relatively unknown. This lack of understanding has limited the development of novel disease-modifying therapies and left the reaso...
Litter quality and stream physicochemical properties drive global invertebrate effects on instream litter decomposition
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Plant litter is the major source of energy and nutrients in stream ecosystems and its decomposition is vital for ecosystem nutrient cycling and functioning. Invertebrates are key contributors to instream litter decomposition, yet quantification of their effects and drivers at the global scale remains lacking. Here, we systematically synthesized dat...
Reply to Pallotti et al. Comment on "Boitrelle et al. The Sixth Edition of the WHO Manual for Human Semen Analysis: A Cr...
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Recommendations for empowering early career researchers to improve research culture and practice
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Early career researchers (ECRs) are important stakeholders leading efforts to catalyze systemic change in research culture and practice. Here, we summarize the outputs from a virtual unconventional conference (unconference), which brought together 54 invited experts from 20 countries with extensive experience in ECR initiatives designed to improve ...
Axon Biology in ALS: Mechanisms of Axon Degeneration and Prospects for Therapy.
Funder: John and Lucille Van Geest Foundation; doi: http://dx.doi.org/10.13039/501100020410 / Funder: Robert Packard Center for ALS Research, Johns Hopkins University; doi: http://dx.doi.org/10.13039/100012312 / This review addresses the longstanding debate over whether amyotrophic lateral sclerosis (ALS) is a 'dying back' or 'dying forward' disord...
Effectiveness of Guided and Open Inquiry Instructional Strategies on Science Process Skills and Self-Efficacy of Biology...
The study determined the effectiveness of guided and open inquiry instructional strategies on the science process skills of students taught Biology in senior secondary schools in Osun State, Nigeria. It also compared the self-efficacy of students taught Biology using guided inquiry with those taught Biology using open inquiry instructional strategi...
