Design, development, productization, and applications of advanced product concepts are pressing for higher multifunctionality, resilience, and maximization of available resources equitably to meet the growing and continuing demands of global customers. These demands have further accelerated during the recent COVID19 pandemic and are continuing to b...
Microwave dielectric spectroscopy of biological materials is gaining interest as it presents attractive features such as being noninvasive, rapid, label-free, and suitable for intracellular investigations, notably for biological and medical researches. Specific microwave biosensors have consequently been developed to investigate biomolecules, cells...
Ludwig van Beethoven (1770-1827) remains among the most influential and popular classical music composers. Health problems significantly impacted his career as a composer and pianist, including progressive hearing loss, recurring gastrointestinal complaints, and liver disease. In 1802, Beethoven requested that following his death, his disease be de...
The complex pharmacology of G-protein-coupled receptors (GPCRs) is defined by their multi-state conformational dynamics. Single-molecule Förster Resonance Energy Transfer (smFRET) is well suited to quantify dynamics for individual protein molecules; however, its application to GPCRs is challenging. Therefore, smFRET has been limited to studies of i...
Published in IOP Conference Series: Earth and Environmental Science
The flower of the jamblang plant (Syzygium cumini (L.) Skeels) is a type of compound flower. The jamblang flowers have a panicle like shape with branches that are far apart. The phenology study has practical importance for planning the plant breeding program, including if there will be the development of superior jamblang varieties. The purpose of ...
CF (Cystic Fibrosis) is the most prevalent genetic disease among Caucasians. Here, a sodiumbicarbonate channel, the Cystic Fibrosis Transmembrane conductance Regulator (CFTR), is impaired, dehydrating all epithelia. The principal cause of morbimortality of CF is CF lung disease (CFLD) where CF airways have impaired mucociliary clearance and undergo...
The mammalian multicopper ferroxidases (MCFs) ceruloplasmin (CP), hephaestin (HEPH) and zyklopen (ZP) comprise a family of conserved enzymes that are essential for body iron homeostasis. Each of these enzymes contains six biosynthetically incorporated copper atoms which act as intermediate electron acceptors, and the oxidation of iron is associated...
PurposeAlpelisib is a PI3K alpha (PI3Kα)-selective inhibitor approved for the treatment of hormone receptor-positive/HER2-negative (HR+/HER2-) PIK3CA-mutated advanced breast cancer (ABC) based on the SOLAR-1 trial, which defined 11 substitutions in exons 7, 9, and 20 in PIK3CA (SOLAR1m). We report alpelisib effectiveness for ABC harboring SOLAR1m, ...
status: published
Classic theories of stress and health are largely based on assumptions regarding how different psychosocial stressors influence biological processes that, in turn, affect human health and behavior. Although theoretically rich, this work has yielded little consensus and led to numerous conceptual, measurement, and reproducibility issues. Social Safe...
