The female reproductive system is coupled with circadian rhythms, and circadian disruption is associated with decreased reproductive capacity. For example, the preovulatory luteinizing hormone (LH) surge is temporally regulated. In the hypothalamus, the suprachiasmatic nucleus (SCN) sends projections to the kisspeptin and gonadotropin-releasing hor...
Maxillary palatal expansion has several relevant uses, including correction of transverse discrepancies and maxillary constriction, improving masticatory function, and improving the airway volume of the nasopharynx. Mid-palatal expansion can be completed by splitting the median suture with either a bone-borne or a tooth-borne expander. If the bone ...
Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic protein that is highly expressed in the myocardium and plays a critical role in maintaining cardiac homeostasis. Cardiac-specific MCL-1-knockout mice develop rapid cardiac dysfunction and cardiomyopathy but show little activation of apoptotic cell death. Instead, loss of MCL-1 resulted in atypica...
Plants have evolutionarily developed mechanisms that enable them to adapt and respond to environmental stimuli, increasing plant survivability. A key component involved in these mechanisms are stomatal pores that regulate gas exchange. Stomatal pores are in charge of regulating the intake of CO2, which is used during photosynthesis to create energy...
The study of cancer-immune dynamics is broad. There are myriad instances of these dynamics and much heterogeneity among the two. To explore these relationships in their fullness, mathematical modeling is used to go further faster than can be done by experiments alone. In this work, two models of cancer-immune dynamics are explored and their applica...
Throughout the cell cycle, genome duplication is coordinated with the multiplication and growth of organelles, which requires membrane biosynthesis at the endoplasmic reticulum (ER). By this reasoning, ER growth and increased ER function would be a pre-requisite for cell division. Because the unfolded protein response (UPR)—a fundamental homeostati...
Juvenile mermithid nematodes are endoparasitic worms that infect and kill their arthropod hosts, typically insects. Here, we provide the first report of a mermithid infecting a marine decapod crustacean. In an initial parasitological survey in December 2018, we encountered juveniles of a new mermithid species infecting the hemocoel of Hemigrapsus o...
In the marine environment, political borders are essentially imaginary lines that often divide well-connected populations, communities and habitats. Scientific evidence shows that collaboration among nations can improve the effectiveness of program management, conservation, and cost efficiency. Despite the evidence that the marine region between Ca...
Marine mammals rely on oxygen stored in blood, muscle, and lungs to support breath-hold diving and foraging at sea. Here, we used biomedical imaging to examine lung oxygen stores and other key respiratory parameters in living ringed seals (Pusa hispida). Three-dimensional models created from CT images were used to quantify total lung capacity (TLC)...
Pulmonary arterial hypertension (PAH) is a devastating disease that is often misdiagnosed. PAH is characterized by the remodeling of the small resistance arteries in the lungs that leads to elevated right ventricular pressure (RVP) and cardiac failure. Endothelial cells can sense danger or damage to the arterial wall caused by mechanical injury or ...
