Eosinophilic Esophagitis (EoE) is an allergic/immune disease of the esophagus that is triggered by food or airborne allergens that invade and damage the esophagus and is distinguished by abnormal presence of eosinophils in the esophagus. This invasion can activate the epithelial layers of the esophagus to initiate a cascade of damaging immune respo...
Major depressive disorder (MDD) and other depressive disorders are highly prevalent in the world today. A pervasive and debilitating symptom of MDD, that is also seen in other depressive disorders, is anhedonia – the lack of interest or pleasure, a consequence of dysfunction of reward circuits. Chronic stress induces anhedonia in susceptible, but n...
The goal of biomedical research is first to understand the mechanism of the diseases, then develop a therapy to mitigate such disease. In the process, animal models and in vitro culture systems comprising primary human cells would be utilized as a study platform. An in vitro system representing small intestine is of great interest. However, attempt...
Invasive species cause substantial ecological and economic damages. While major modelling improvements have been made in the last decades, predictions are primarily based on single species analyses, look at a single factor at a time (i.e. environmental conditions, species traits, and propagule pressure, individually), and consider quite broad stage...
Abstract INTRODUCTION: Different blood meal sources can affect biology of triatomines. METHODS: We studied the influence of two different blood meal sources (rabbits and hens) on five biological parameters in Meccus phyllosomus pallidipennis and collected biological parameters. RESULTS: The cohort fed on rabbits had a shorter median life-cycle and ...
The development of therapeutic agent against cancer is based on targeting key signaling proteins that cancer highjacks and uses to survive. Although progress has been made to define cancer’s vulnerabilities, a subset of cancer drivers remain undruggable. To address this problem the field has attempted to identify drug targets that would selectively...
The development of pulp capping agents has been instrumental in promoting reparative dentin formation and facilitating pulpal repair in response to pulp exposure during extensive caries excavation. Although calcium hydroxide has been used as the gold standard for pulp capping since decades, the development of mineral trioxide aggregate (MTA) and it...
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) affect 75-100 million U.S. citizens and carries an increased risk for liver, cardiovascular and cancer related morbidity and mortality. Similarly, chronic hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma (HCC) worldwide...
Biological assays typically employ large numbers of constituent agents (virus particles, fluorescing antibodies, oligonucleotides, etc) to quantitatively measure the effects of various natural processes such as virus infectivity, cell membrane receptor concentrations, and the binding affinity of biomarkers. For the simplicity of analysis, these ass...
The coevolution between hosts and their endosymbionts (organisms that live only in the host’s body and cells), has dramatically shaped the history of life. Symbiotic relationships can range from mutualism to parasitism, as observed in the diverse relationships between arthropod hosts and obligately intracellular α-proteobacterium from the genus, Wo...
