Shi, Linling Wei, Lun Lu, Meiqiu Ding, Hongmei Bo, Le
Published in
BMC pregnancy and childbirth
To explore the biological relationship between the regulatory signal pathways involved in differentially expressed genes and recurrent spontaneous abortion (RSA) by analyzing the gene expression microarray data of unexplained RSA. The gene expression profile data of chorionic villi from unexplained recurrent abortion with normal karyotype and selec...
Song, Yang Zhao, Yi Zhang, Xiaodi Cheng, Cheng Yan, Haidong Liu, Daxing Zhang, Dengshen
Published in
BMC cardiovascular disorders
To screen Myocardial ischemia-reperfusion Injury in mice. adenosine monophate-activatedprotein kinase (AMPK) -related differentially expressed circularRNA (circRNA) in MIRI model, Ampk-related circRNA network was drawn to provide possible ideas for the prevention and treatment of MIRI. The mouse MIRI model was constructed by ligation of the left an...
Yang, Deyi Li, Pengchong Dang, Yan Zhu, Shengtao Shi, Haiyun Wu, Ting Zhang, Zinan Chen, Chuyan Zong, Ye
Published in
Gene
Crohn's disease (CD) is marked by disruption of intestinal epithelial barrier, with unclear underlying molecular mechanisms. This study aimed to investigate key genes regulating the intestinal barrier in CD patients. Differential gene expression analysis and gene set enrichment analysis were conducted to identify potential key genes involved in CD ...
Wang, Feng-Lin Zhou, Yan-Nan Zhang, Guang-Ting Ran, Yin Yang, Xin-Xin Zhou, Lin Zhu, Zhao-Qiong Zhang, Yu Liu, De-Xing
Published in
International immunopharmacology
The incidence of sevoflurane-related adverse respiratory events in children with asthma is notably high. During different phases of sevoflurane anesthesia, asthmatic children's airways are exposed to varying concentrations of the anesthetic. However, the specific effects of different concentrations of sevoflurane on the developing airways with asth...
Kazemi, Masoumeh Naghdi Sadeh, Reza Shekari Khaniani, Mahmoud Rezazadeh, Maryam Derakhshan, Sima Mansoori Ghafouri-Fard, Soudeh
Published in
Scientific reports
Alzheimer's disease (AD) is a degenerative illness that accounts for the common type of dementia among adults over the age of 65. Despite extensive studies on the pathogenesis of the disease, early diagnosis of AD is still debatable. In this research, we performed bioinformatics approaches on the AD-related E-MTAB 6094 dataset to uncover new potent...
Liu, Siyi Chen, Haitao Yang, Xu Wen, Yinxian Chen, Liaobin
Published in
Scientific reports
Lines of evidence have indicated that type 2 diabetes mellitus (T2DM) is an independent risk factor for osteoarthritis (OA) progression. However, the study focused on the relationship between T2DM and OA at the transcriptional level remains empty. We downloaded OA- and T2DM-related bulk RNA-sequencing and single-cell RNA sequencing data from the Ge...
Xing, Haihua Wang, Qianghui Ma, Yukai Han, Ruobing Li, Heping
Published in
Gene expression patterns : GEP
Deer antlers exhibit rapid growth during the velvet phase. As a critical endogenous growth factor in animals, midkine (MDK) is likely closely associated with the growth of antlers. However, the spatio-temporal expression pattern of MDK during the velvet phase was unclear. This study explored the physiological role of MDK by analyzing its molecular ...
Roy, Somak Fussell, Amber Jordan, Danielle Kadri, Sabah Leon, Annette Schmidt, Ryan J Temple-Smolkin, Robyn L Merker, Jason D
Published in
The Journal of molecular diagnostics : JMD
The use of next-generation sequencing (NGS) and other high-throughput technologies in the clinical molecular diagnostics laboratory requires the application of bioinformatics pipelines and other computational tools to analyze, visualize, and store these clinical data. Clinical Bioinformaticians, individuals with the skills to develop, validate, and...
Franken, Amelie Bila, Michel Lambrechts, Diether
The spatial organization of cells within tissues aids in understanding physiological and pathological processes, as well as elucidating the mechanisms of action underlying treatments. We present a protocol for analyzing image-based spatial proteomics data. To illustrate, we focus on whole-slide images of human multiplexed tumor tissues acquired usi...
Hu, Xun Xu Lou, Inmaculada Chen, Qilan
Published in
Arthritis research & therapy
Accumulated evidence supports the tendency of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis(AAV) to coexist with atherosclerosis (AS). However, the common etiology of these two diseases remains unclear. This study aims to explore the mechanisms underlying the concurrent occurrence of ANCA and AS. Microarray data of AAV and AS wer...
