A Stable and Sensitive TLC-Spray for Thiols, Disulfides and Thioesters
status: published
Porocarcinoma: Clinical and Histological Features, Immunohistochemistry and Outcomes: A Systematic Review
Porocarcinoma (PC) is a rare adnexal tumor, mainly found in the elderly. The tumor arises from the acrosyringium of eccrine sweat glands. The risk of lymph node and distant metastasis is high. Differential diagnosis with squamous cell carcinoma is difficult, although NUT expression and YAP1 fusion products can be very useful for diagnosis. Currentl...
Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration
MicroRNAs (miRs) are short, evolutionarily conserved noncoding RNAs that canonically downregulate expression of target genes. The miR family composed of miR-204 and miR-211 is among the most highly expressed miRs in the retinal pigment epithelium (RPE) in both mouse and human and also retains high sequence identity. To assess the role of this miR f...
The Effect of Body Mass Index on Melanoma Biology, Immunotherapy Efficacy, and Clinical Outcomes: A Narrative Review
Recent studies indicate that a higher body mass index (BMI) might correlate with improved responses to melanoma treatment, especially with immune checkpoint inhibitors (ICIs), despite the general association of obesity with an increased risk of cancer and higher mortality rates. This review examines the paradoxical relationship between BMI and clin...
A comparative study of analytical models of diffuse reflectance in homogeneous biological tissues: Gelatin-based phantom...
Information about tissue oxygen saturation (StO2) and other related important physiological parameters can be extracted from diffuse reflectance spectra measured through non-contact imaging. Three analytical optical reflectance models for homogeneous, semi-infinite, tissue have been proposed (Modified Beer-Lambert, Jacques 1999, Yudovsky 2009) but ...
Ablation of Vitamin D Signaling in Cardiomyocytes Leads to Functional Impairment and Stimulation of Pro-Inflammatory and...
The association between vitamin D deficiency and cardiovascular disease remains a controversial issue. This study aimed to further elucidate the role of vitamin D signaling in the development of left ventricular (LV) hypertrophy and dysfunction. To ablate the vitamin D receptor (VDR) specifically in cardiomyocytes, VDRfl/fl mice were crossed with M...
Antibacterial activity, cytotoxicity and chemotaxonomic significance of chemical constituents from Alsophila manniana Ho...
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status: published
How medical schools can prepare students for new technologies
status: published
A Narrative Review of the Role of Estrogen (Receptors) in Melanoma
In this narrative review, we attempt to provide an overview of the evidence regarding the role of estrogen (receptors) in cutaneous melanoma (CM). We reviewed 68 studies and 4 systematic reviews and meta-analyses published from 2002 up to and including 2022. The prevailing presence of estrogen receptor β (ERβ) instead of estrogen receptor α (ERα) i...
Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibit...
In pursuit of enhancing the anti-resistance efficacy and solubility of our previously identified NNRTI 1, a series of biphenyl-quinazoline derivatives were synthesized employing a structure-based drug design strategy. Noteworthy advancements in anti-resistance efficacy were discerned among some of these analogs, prominently exemplified by compound ...
