Comment on: “Management of Alcohol Dependence in Patients With Liver Disease”
Published in CNS Drugs
Short-interval and long-interval intracortical inhibition of TMS-evoked EEG potentials.
Published in Brain stimulation
Inhibition in the human motor cortex can be probed by means of paired-pulse transcranial magnetic stimulation (ppTMS) at interstimulus intervals of 2-3 ms (short-interval intracortical inhibition, SICI) or ∼100 ms (long-interval intracortical inhibition, LICI). Conventionally, SICI and LICI are recorded as motor evoked potential (MEP) inhibition in...
GABAB receptor ligand-directed trimethyl chitosan/tripolyphosphate nanoparticles and their pMDI formulation for survivin...
Published in Carbohydrate polymers
The effect of gene silencing by survivin siRNA (siSurvivin) on the proliferation and apoptosis of lung tumor has been attracted more interest. GABAB receptor ligand-directed nanoparticles consisting of baclofen functionalized trimethyl chitosan (Bac-TMC) as polymeric carriers, tripolyphosphate (TPP) as ionic crosslinker, and siSurvivin as therapeut...
A Clinical Study on Comparative Evaluation of the Effectiveness of Carbamazepine and Combination of Carbamazepine with B...
Published in Nigerian journal of surgery : official publication of the Nigerian Surgical Research Society
Trigeminal neuralgia (TN) is characterized by recurrent attacks of lancinating pain in the trigeminal nerve distribution. Various medicinal and surgical procedures have been utilized for the treatment of TN. Over the time, several drugs other than carbamazepine have been used but none of them have shown satisfying results. The objective of the stud...
An investigation of the relationship between autonomic dysreflexia and intrathecal baclofen in patients with spinal cord...
Published in The journal of spinal cord medicine
To study the relationship between autonomic dysreflexia and intrathecal baclofen in patients with spinal cord injury. Retrospective chart review. Inpatient and outpatient acute rehabilitation facility. Thirty-four subjects. We reviewed patients' medical records to ascertain the presence of symptomatic autonomic dysreflexia (AD) prior to and after i...
Sleep-Related Painful Erections: A Meta-Analysis on the Pathophysiology and Risks and Benefits of Medical Treatments.
Published in The journal of sexual medicine
Patients with sleep-related painful erections (SRPEs) have frequent awakenings from deep penile pain during nocturnal erections. This results in severe sleep deprivation. To review the current literature on SRPEs and discuss the pathophysiologic theories and risks and benefits of medical treatments. PubMed was searched using the terms sleep-related...
Protocadherin 10 alters γ oscillations, amino acid levels, and their coupling; baclofen partially restores these oscilla...
...Published in Neurobiology of disease
Approximately one in 45 children have been diagnosed with Autism Spectrum Disorder (ASD), which is characterized by social/communication impairments. Recent studies have linked a subset of familial ASD to mutations in the Protocadherin 10 (Pcdh10) gene. Additionally, Pcdh10's expression pattern, as well as its known role within protein networks, im...
Interventions for managing skeletal muscle spasticity following traumatic brain injury
Published in The Cochrane Database of Systematic Reviews
Review question We reviewed the evidence about the effect of treatments (drug and non‐drug) for spasticity following a brain injury caused by a blow to the head (traumatic brain injury (TBI)). Background Many people with TBI experience muscle spasticity, when their muscles contract or tighten involuntarily. This can impact on a person's ability to ...
Baclofen and naltrexone effects on alcohol self-administration: Comparison of treatment initiated during abstinence or o...
Published in Drug and alcohol dependence
Baclofen, a GABAB receptor agonist, is under investigation as a pharmacotherapy for alcohol use disorder. Treatment with a pharmacotherapeutic can be initiated during alcohol abstinence or active drinking, which may influence treatment outcomes. This study examined whether baclofen treatment initiated and maintained during alcohol abstinence would ...
Lateral septum stimulation disinhibits dopaminergic neurons in the antero-ventral region of the ventral tegmental area: ...
Published in Neuropharmacology
The mechanisms commanding the activity of dopaminergic neurons of the ventral tegmental area (VTA) and the location of these neurons are relevant for the coding and expression of motivated behavior associated to reward-related signals. Anatomical evidence shows that several brain regions modulate VTA dopaminergic neurons activity via multiple mecha...
