Critical Reviews in Neurosurgery
Partial dorsal root rhizotomy and intrathecal administration of baclofen are two modalities used to treat spasticity in children. Each has its own inclusion criteria and mechanism of action. Both have been proven to relieve spasticity, and both have their particular side effects and complications. Programmable pumps for the accurate and reliable ad...
Naunyn-Schmiedeberg's Archives of Pharmacology
Previous studies have shown that administration of γ-hydroxybutyric acid (GHBA) or the GABAB receptor agonist baclofen are associated with a decrease in firing rate, a regularisation of firing pattern and a decrease in burst activity of midbrain dopamine (DA) neurons in the substantia nigra (SN). In the present study we compared the ability of the ...
The effect of pretreatment with pertussis toxin at the doses of 0.25 and 0.50 μg per mouse ICV on the amnesic effect produced by baclofen (0.1–4 mg kg−1 IP), diphenhydramine (15–30 mg kg−1 IP) and scopolamine (0.5–5 mg kg−1 IP) was investigated in the mouse passive avoidance test. Ten days after a single injection of pertussis toxin, baclofen (2–4 ...
Chronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of γ-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism. Recently, in normal subjects, we have demonstrate...
BBA - Biomembranes
Intestinal transport of baclofen ( β-( p-chlorophenyl)- γ-aminobutyric acid) in the rat has been examined in vitro. Influx of baclofen across the brush-border membrane ( J mc Bacl) and steady-state accumulation by everted segments of the intestine were measured. J mc Bacl could be accounted for as the sum of a saturable process with a maximum rate ...
Current Treatment Options in Neurology
Canadian Journal of Anesthesia
PurposeTo evaluate the performance of the Panomat® P-10 micro-volumetric infusion pump for its use in drug administration at minimal flow rates (μL·hr−1; e.g., intrathecal application).MethodsFluid delivery at steady state conditions, and after vertical displacement of the syringe pump by −50 cm was determined gravimetrically. The Panomat® P-10 inf...