McLaughlin, Matthew J. Abdel-Rahman, Susan Leeder, J. Steven
Published in
Current Physical Medicine and Rehabilitation Reports
Purpose of ReviewDespite its widespread use, oral baclofen requires a critical review of the pharmacology to determine potential precision medicine applications to improve medication administration. Discussing the dose→exposure→response relationship of oral baclofen allows a conceptual framework in which designing clinical trials would become more ...
Ruggiero, Claudio Meccariello, Giulia Spennato, Pietro Mirone, Giuseppe Graziano, Stefania Gilone, Marco Cinalli, Giuseppe
Published in
Child's Nervous System
IntroductionIntrathecal baclofen (ITB) is an effective treatment for managing primary and secondary dystonia. Intraventricular baclofen (IVB) was first developed to allow treating patients in which the use of ITB was difficult due to anatomic anomalies. After that, several studies indicate that intraventricular administration of baclofen, is more e...
Bowman, Angeline Ayyangar, Rita Gonzales, Ian Hornyak, Joseph
Published in
Journal of pediatric rehabilitation medicine
A 9-year old male patient with a past medical history of congenital cytomegalovirus (CMV) infection and spastic quadriplegic cerebral palsy with an intrathecal baclofen pump was admitted to a tertiary care hospital with respiratory depression and unresponsiveness for approximately two days. He had a recent two-week hospital stay for respiratory fai...
Habibian, Sonia Ahamad, Keith McLean, Mark Socias, Maria Eugenia
Published in
Journal of addiction medicine
Gamma-hydroxybutyrate (GHB)-a GABA-B agonist-can lead to a use disorder, and a withdrawal syndrome similar to that of alcohol. At present, evidence is lacking for how to best manage GHB withdrawal, and often clinicians rely on alcohol withdrawal management approaches, using medications like benzodiazepines (BZD). However, BZD doses needed to contro...
Savage, Sharon Hoefeijzers, Serge Milton, Fraser Streatfield, Claire Dewar, Michaela Zeman, Adam
Published in
Cortex; a journal devoted to the study of the nervous system and behavior
Accelerated long-term forgetting (ALF) occurs when newly learned information decays faster than normal over extended delays. It has been recognised most frequently in temporal lobe epilepsy, including Transient Epileptic Amnesia (TEA), but can also be drug-induced. Little is known about the evolution of ALF over time and its impacts upon other memo...
Khazneh, Emad Shamlawi, Alaa Jebrin, Kamel Hamdan, Zakaria Sawalmeh, Osama
Published in
BMC Nephrology
BackgroundBaclofen is a centrally acting GABAB receptor agonist and it is used widely for the treatment of spasticity, persistent hiccups and multiple sclerosis. The renal system is the main route of excretion, thus people with suboptimal renal function are prone to baclofen intoxication. Multiple doses of baclofen have been associated with toxicit...
Palmieri, Solène
Rationnel : le baclofène, agoniste des récepteurs GABAB, est de plus en plus utilisé pour traiter l’alcoolo-dépendance entraînant un surcroit de cas d’intoxication. Les études précliniques et cliniques suggèrent l’apparition d’un syndrome de sevrage suite à l’arrêt brutal d’un traitement prolongé. Nos objectifs étaient de caractériser le sevrage au...
Sorrieul, J Robert, J Gibory, V Kieffer, H Folliard, C Dupoiron, D Devys, C
Published in
Annales pharmaceutiques francaises
Intrathecal analgesia is a method using various molecules alone or in combination. Among these, the association sufentanil/ baclofen is widely used. Instead of moving patients to the few expert centers taking charge of these specific preparations, it could be better to transport syringes to peripheral centers managing pump refilling. That is why, i...
Kotmanova, Z Simera, M Veternik, M Martvon, L Misek, J Jakus, J Shen, T Y Musselwhite, M N Pitts, T Bolser, D C
...
Published in
Respiratory physiology & neurobiology
GABA, muscimol, and baclofen were microinjected into the rostral (rNTS) and caudal solitary tract nucleus (cNTS) in 24 anesthetized cats. Electromyograms (EMGs) of diaphragm (DIA) and abdominal muscles (ABD), blood pressure and esophageal pressure (EP) were recorded and analysed. Bilateral microinjections of 1 mM GABA (total 66 ± 4 nl), 1 mM baclof...
Holla, Bharath Karthik, Sheshachala Biswal, Jitendriya Viswanath, Biju Jayarajan, Deepak Bharath, Rose Dawn Venkatasubramanian, Ganesan Benegal, Vivek
Published in
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
Baclofen is a promising treatment for alcohol use disorders (AUD), although its clinical response in humans is mixed. The present study aimed at investigating the impact of baclofen treatment on cue-induced brain activation pattern and its relationship with relapse outcomes. Twenty-three inpatients with AUD underwent a functional magnetic resonance...
