Cedillo, Laura N Ruíz-García, Rosa Isela Jiménez, Juan C Miranda, Florencio
Published in
Experimental brain research
GABAB and 5-HT2C agonists are effective in attenuating the behavioral effects of psychostimulants. However, they induce adverse side effects when used in high doses. The previous evidence has suggested that the 5HT2C receptor activation effect could be produced by an increased release of GABA in the ventral tegmental area (VTA) and the consequent a...
El-Yazbi, Amira F Guirguis, Karin M Bedair, Mona M Belal, Tarek S
Published in
Heliyon
This study demonstrates three simple and inexpensive spectrophotometric mix-and-read assays for the determination of the skeletal muscle relaxant, baclofen (BAC) in pharmaceutical formulations. The proposed methods are based on the reaction of the primary amine group of BAC with various derivatizing reagents to yield different colored products. Met...
Braillon, Alain Naudet, Florian
Published in
Hepatology (Baltimore, Md.)
Pucks-Faes, Elke Matzak, Heinrich Hitzenberger, Gabriel Genelin, Eleonora Halbmayer, Lucas-Michael Fava, Elena Fritz, Josef Saltuari, Leopold
Published in
Archives of physical medicine and rehabilitation
To report our experience using continuous intrathecal baclofen (ITB) administration prior to a possible ITB device implantation. Retrospective open label study. Mean duration of follow-up 64 months. Primary-care and referral center, ambulatory and hospitalized care. Patients (N=116) undergoing continuous ITB trials between 2006 and 2017. Continuous...
Lake, Wendell Shah, Hamid
Published in
Neurosurgery clinics of North America
Intrathecal baclofen infusion is an accepted treatment for spasticity. Evidence also exists for the treatment of secondary generalized dystonia with intrathecal baclofen infusion. Benefits include decreased tone, improved positioning, and decreased decubitus ulcers. Despite these benefits, there are significant complications that can occur with thi...
Jouney, Edward A.
Published in
Current Psychiatry Reports
Purpose of ReviewPhenibut (β-phenyl-γ-aminobutyric acid) is a psychoactive GABA analogue currently being marketed online as an anxiolytic and nootropic dietary supplement. Its use is growing in popularity, but its pharmacological activity is well beyond that of a conventional nutritional supplement, and similar to that of a prescription strength se...
Im, Gene Y.
Published in
Current Hepatology Reports
Purpose of ReviewThis review provides a brief overview of key concepts in addiction medicine and provides tips and tricks as it pertains to treating patients with alcohol addiction in the setting of advanced alcohol-related liver disease (ALD).Recent FindingsUnderstanding the brain disease model of addiction by both providers and patients is a vita...
McLaughlin, Matthew J. Abdel-Rahman, Susan Leeder, J. Steven
Published in
Current Physical Medicine and Rehabilitation Reports
Purpose of ReviewDespite its widespread use, oral baclofen requires a critical review of the pharmacology to determine potential precision medicine applications to improve medication administration. Discussing the dose→exposure→response relationship of oral baclofen allows a conceptual framework in which designing clinical trials would become more ...
Ruggiero, Claudio Meccariello, Giulia Spennato, Pietro Mirone, Giuseppe Graziano, Stefania Gilone, Marco Cinalli, Giuseppe
Published in
Child's Nervous System
IntroductionIntrathecal baclofen (ITB) is an effective treatment for managing primary and secondary dystonia. Intraventricular baclofen (IVB) was first developed to allow treating patients in which the use of ITB was difficult due to anatomic anomalies. After that, several studies indicate that intraventricular administration of baclofen, is more e...
Bowman, Angeline Ayyangar, Rita Gonzales, Ian Hornyak, Joseph
Published in
Journal of pediatric rehabilitation medicine
A 9-year old male patient with a past medical history of congenital cytomegalovirus (CMV) infection and spastic quadriplegic cerebral palsy with an intrathecal baclofen pump was admitted to a tertiary care hospital with respiratory depression and unresponsiveness for approximately two days. He had a recent two-week hospital stay for respiratory fai...
