Published in Neuromodulation : journal of the International Neuromodulation Society
The objective of this study was to evaluate the accuracy and precision of SynchroMed II programmable infusion pumps for delivery of intrathecal baclofen to treat severe spasticity. Retrospective chart review study. Urban academic rehabilitation clinic. Patients with spasticity treated with intrathecal baclofen. A retrospective chart review of 149 p...
Published in Data in Brief
In the intensive care unit, alcohol intake above the NIAAA recommendations regardless of the existence of an Alcohol Use Disorder (AUD), was associated with an increased risk of death and longer time on ventilator. This rises the hypothesis that unhealthy alcohol use may lead to specific issues when weaning the mechanical ventilation (i.e. agitatio...
Published in Experimental brain research
GABAB and 5-HT2C agonists are effective in attenuating the behavioral effects of psychostimulants. However, they induce adverse side effects when used in high doses. The previous evidence has suggested that the 5HT2C receptor activation effect could be produced by an increased release of GABA in the ventral tegmental area (VTA) and the consequent a...
Published in Heliyon
This study demonstrates three simple and inexpensive spectrophotometric mix-and-read assays for the determination of the skeletal muscle relaxant, baclofen (BAC) in pharmaceutical formulations. The proposed methods are based on the reaction of the primary amine group of BAC with various derivatizing reagents to yield different colored products. Met...
Published in Hepatology (Baltimore, Md.)
Published in Archives of physical medicine and rehabilitation
To report our experience using continuous intrathecal baclofen (ITB) administration prior to a possible ITB device implantation. Retrospective open label study. Mean duration of follow-up 64 months. Primary-care and referral center, ambulatory and hospitalized care. Patients (N=116) undergoing continuous ITB trials between 2006 and 2017. Continuous...
Published in Neurosurgery clinics of North America
Intrathecal baclofen infusion is an accepted treatment for spasticity. Evidence also exists for the treatment of secondary generalized dystonia with intrathecal baclofen infusion. Benefits include decreased tone, improved positioning, and decreased decubitus ulcers. Despite these benefits, there are significant complications that can occur with thi...
Published in Current Psychiatry Reports
Purpose of ReviewPhenibut (β-phenyl-γ-aminobutyric acid) is a psychoactive GABA analogue currently being marketed online as an anxiolytic and nootropic dietary supplement. Its use is growing in popularity, but its pharmacological activity is well beyond that of a conventional nutritional supplement, and similar to that of a prescription strength se...
Published in Current Hepatology Reports
Purpose of ReviewThis review provides a brief overview of key concepts in addiction medicine and provides tips and tricks as it pertains to treating patients with alcohol addiction in the setting of advanced alcohol-related liver disease (ALD).Recent FindingsUnderstanding the brain disease model of addiction by both providers and patients is a vita...
Published in Current Physical Medicine and Rehabilitation Reports
Purpose of ReviewDespite its widespread use, oral baclofen requires a critical review of the pharmacology to determine potential precision medicine applications to improve medication administration. Discussing the dose→exposure→response relationship of oral baclofen allows a conceptual framework in which designing clinical trials would become more ...
