Tian, Runhui Guo, Kaimin Wu, Bo Wang, Hongbo
Published in
Molecular and Cellular Biochemistry
Shrm4 is a protein that is exclusively expressed in polarized tissues. The physiological function of Shrm4 in the brain was required to be elucidated. Thus, we aimed to explore how the Shrm4-mediated gamma-aminobutyric acid (GABA) pathway affected neural stem cells (NSCs). At first, the Nestin expression in cultured NSCs was identified. After deter...
De Andrés, José Rubio-Haro, Rubén De Andres-Serrano, Carmen Asensio-Samper, Juan Marcos Fabregat-Cid, Gustavo
Published in
Methods in molecular biology (Clifton, N.J.)
Targeted intrathecal (IT) drug delivery systems (IDDS) are well established as an effective treatment of patients with chronic nonmalignant or malignant pain, and as a tool for management of patients with severe spasticity. The risk to benefit ratio of IDD makes it a relatively safe therapy for both cancer- and noncancer-related pain, but it is not...
Talaei, Bahareh Fathi Vavsari, Vaezeh Balalaie, Saeed Arabanian, Armin Bijanzadeh, Hamid Reza
Published in
Iranian Journal of Pharmaceutical Research : IJPR
Small peptides are valuable peptides due to their extended biological activities. Their activities could be categorized according to their low antigenicity, osmotic pressure, and also because of their astonishing bioactivities. For example, the aggression of Phe-Phe fibers via self-assembly and intermolecular hydrogen bonding is the main reason for...
Mahdavinasab, Seyedeh-Mahsa Saghazadeh, Amene Motamed-Gorji, Nogol Vaseghi, Salar Mohammadi, Mohammad-Reza Alichani, Rosa Akhondzadeh, Shahin
Published in
European child & adolescent psychiatry
Increasing evidence suggests that the function of the GABAergic system is abnormally low in autism spectrum disorder (ASD). Baclofen, which functions as a selective agonist for GABAB receptors, does appear promising for the treatment of ASD. We conducted a 10-week randomized-controlled study aimed at evaluating the potential of baclofen as an adjuv...
Fioravanti, C Kajal, S D Carboni, M Mazzetti, C Ziemann, U Braun, C
Published in
NeuroImage
The presented study investigates the functional role of GABA in somatosensory processing, using a combined neuropharmacological-neuroimaging approach. Three different GABA agonists (GABAA: alprazolam, ethanol; GABAB: baclofen) were investigated in a double blind cross-over design in 16 male participants, accomplishing a tactile perception task. Som...
Levy, Jonathan Lansaman, Thibaud Frémondière, Flavie Ferrapie, Anne-Laure Sher, Avigaelle Dinomais, Mickael Bensmail, Djamel
Published in
Annals of physical and rehabilitation medicine
Skoog, Bengt Hedman, Björn
Published in
Annals of Rehabilitation Medicine
Objective To investigate dosage changes in intrathecal baclofen during long-term treatment of patients with severe leg spasticity. Methods We performed a retrospective chart review of 49 patients treated with an intrathecal baclofen pump (ITB) because of severe leg spasticity, for a minimum of 7 years. Eight patients were excluded due to catheter/p...
Martínez-Campos, Zuleyma Pastor, Nina Pineda-Urbina, Kayim Gómez-Sandoval, Zeferino Fernández-Zertuche, Mario Razo-Hernández, Rodrigo Said
Published in
Chemical biology & drug design
The study of γ-aminobutyric acid B receptor (GABAB ) activation is of great interest for several brain disorders. The search of new GABAB receptor agonists has been carried out by many research groups. As a result, Baclofen has become the prototypical GABAB receptor agonist. However, several attempts have been made to modify its structure to genera...
Farid, Reza Binz, Kirstin Emerson, Jane Anne Murdock, Fred
Published in
Neuromodulation : journal of the International Neuromodulation Society
The objective of this study was to evaluate the accuracy and precision of SynchroMed II programmable infusion pumps for delivery of intrathecal baclofen to treat severe spasticity. Retrospective chart review study. Urban academic rehabilitation clinic. Patients with spasticity treated with intrathecal baclofen. A retrospective chart review of 149 p...
Vourc'h, Mickael Dailly, Eric Hourmant, Yannick Bellouard, Ronan Mahe, Pierre-Joachim Deslandes, Guillaume Grégoire, Matthieu Asehnoune, Karim
Published in
Data in Brief
In the intensive care unit, alcohol intake above the NIAAA recommendations regardless of the existence of an Alcohol Use Disorder (AUD), was associated with an increased risk of death and longer time on ventilator. This rises the hypothesis that unhealthy alcohol use may lead to specific issues when weaning the mechanical ventilation (i.e. agitatio...
