Forsmark, Annabelle Rosengren, Linda Ertzgaard, Per
Published in
Health Economics Review
BackgroundThe Swedish Healthcare Act states that patients should have equal access to healthcare. This study addresses at how this translates to pharmacological treatment of adult spasticity, including injections with botulinum toxin A (BoNT-A) and pumps for intrathecal baclofen (ITB). To address potential economic incentives for treatment differen...
Ala, Shahram Alvandipour, Mina Saeedi, Majid Mansourifar, Mohaddeseh Monajati, Mahila Shiva, Afshin
Published in
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Baclofen is an agonist for a subtype of gamma-amino butyric acid (GABA-B) receptors and traditionally been used for the systemic treatment of spasticity. Topical application of baclofen has been shown to reduce pain in patients with localized neuropathic pain. In this study, we investigate the efficacy of baclofen cream (5%) in reducing postoperati...
Koker, Alper Arslan, Gazi Özden, Ömer Karaarslan, Utku Er, Anıl Duman, Murat Köroğlu, Tolga
Published in
Acta neurologica Belgica
Baclofen is a derivative of gamma-aminobutyric acid, used mainly for the treatment of muscle spasticity. Baclofen overdose can result in severe respiratory depression, autonomic disturbances, seizures and coma. Here we report a 15-year-old girl who was found unresponsive, intubated and admitted to the PICU. On initial presentation, her Glasgow Coma...
Zad, M Bredenoord, A J
Published in
Current treatment options in gastroenterology
Belching is a physiological event that allows venting of swallowed gastric air. Excessive belching is a common presentation to gastroenterology clinics and could be isolated complains or associated with other gastrointestinal problems. PURPOSE OF THIS REVIEW: It is to describe the presentation, diagnosis, and treatment of belching disorders RECENT ...
Tian, Runhui Guo, Kaimin Wu, Bo Wang, Hongbo
Published in
Molecular and Cellular Biochemistry
Shrm4 is a protein that is exclusively expressed in polarized tissues. The physiological function of Shrm4 in the brain was required to be elucidated. Thus, we aimed to explore how the Shrm4-mediated gamma-aminobutyric acid (GABA) pathway affected neural stem cells (NSCs). At first, the Nestin expression in cultured NSCs was identified. After deter...
De Andrés, José Rubio-Haro, Rubén De Andres-Serrano, Carmen Asensio-Samper, Juan Marcos Fabregat-Cid, Gustavo
Published in
Methods in molecular biology (Clifton, N.J.)
Targeted intrathecal (IT) drug delivery systems (IDDS) are well established as an effective treatment of patients with chronic nonmalignant or malignant pain, and as a tool for management of patients with severe spasticity. The risk to benefit ratio of IDD makes it a relatively safe therapy for both cancer- and noncancer-related pain, but it is not...
Mahdavinasab, Seyedeh-Mahsa Saghazadeh, Amene Motamed-Gorji, Nogol Vaseghi, Salar Mohammadi, Mohammad-Reza Alichani, Rosa Akhondzadeh, Shahin
Published in
European child & adolescent psychiatry
Increasing evidence suggests that the function of the GABAergic system is abnormally low in autism spectrum disorder (ASD). Baclofen, which functions as a selective agonist for GABAB receptors, does appear promising for the treatment of ASD. We conducted a 10-week randomized-controlled study aimed at evaluating the potential of baclofen as an adjuv...
Fioravanti, C Kajal, S D Carboni, M Mazzetti, C Ziemann, U Braun, C
Published in
NeuroImage
The presented study investigates the functional role of GABA in somatosensory processing, using a combined neuropharmacological-neuroimaging approach. Three different GABA agonists (GABAA: alprazolam, ethanol; GABAB: baclofen) were investigated in a double blind cross-over design in 16 male participants, accomplishing a tactile perception task. Som...
Levy, Jonathan Lansaman, Thibaud Frémondière, Flavie Ferrapie, Anne-Laure Sher, Avigaelle Dinomais, Mickael Bensmail, Djamel
Published in
Annals of physical and rehabilitation medicine
Skoog, Bengt Hedman, Björn
Published in
Annals of Rehabilitation Medicine
Objective To investigate dosage changes in intrathecal baclofen during long-term treatment of patients with severe leg spasticity. Methods We performed a retrospective chart review of 49 patients treated with an intrathecal baclofen pump (ITB) because of severe leg spasticity, for a minimum of 7 years. Eight patients were excluded due to catheter/p...
