Gao, Jun Gao, Yao Lin, Shixin Zou, Xia Zhu, Yukai Chen, Xintong Wan, Hong Zhu, Hong
Published in
Journal of Ovarian Research
ObjectiveThis study aimed to explore the effects of activating GABAB1 receptor by baclofen on proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of ovarian cancer cells.ResultsOne hundred μmol/L, 200 μmol/L and 300 μmol/L were selected as low, medium and high baclofen concentrations respectively. Cells were divided into ...
Lemée, Jean-Michel Chinier, Eva Bernard, Florian Gallet, Clémentine Menei, Philippe
Published in
Annals of physical and rehabilitation medicine
Nahar, Limon Khatun Murphy, Kevin G Paterson, Sue
Published in
Journal of analytical toxicology
Baclofen (BLF) has been prescribed in the UK since 1972 for the alleviation of spasticity. However, evidence suggests BLF is also recreationally misused. It has been associated with ethanol, gamma-hydroxybutyric acid (GHB), pregabalin (PGL) and gabapentin (GBP) use/abuse and deaths have been reported. With current postmortem (PM) toxicological scre...
Nahar, LK Murphy, KG Paterson, S
Baclofen (BLF) has been prescribed in the UK since 1972 for the alleviation of spasticity. However, evidence suggests BLF is also recreationally misused. It has been associated with ethanol, gamma-hydroxybutyric acid (GHB), pregabalin (PGL) and gabapentin (GBP) use/abuse and deaths have been reported. With current postmortem (PM) toxicological scre...
Zhang, Mengru Zhu, Yiqing Dong, Ran Qiu, Zhongmin
Published in
Journal of Thoracic Disease
Refractory gastroesophageal reflux-induced chronic cough (GERC) is a special type of gastroesophageal reflux disease (GERD) with predominant cough resistant to pragmatic standard anti-reflux therapy including antisecretory agents alone or in combination with promotility agents but with a favorable response to intensified anti-reflux treatment. The ...
Zikos, Thomas A. Clarke, John O.
Published in
Current Gastroenterology Reports
Purpose of ReviewThis narrative review focuses on the presentation, contributing factors, diagnosis, and treatment of non-acid reflux. We also propose algorithms for diagnosis and treatment.Recent FindingsThere is a paucity of recent data regarding non-acid reflux. The recent Porto and Lyon consensus statements do not fully address non-acid reflux ...
Reynolds, Kimberly Kaufman, Robert Korenoski, Amanda Fennimore, Laura Shulman, Joshua Lynch, Michael
Published in
Clinical toxicology (Philadelphia, Pa.)
Context: Prescriptions for nonopioid pharmacological therapies such as gabapentin and baclofen have been increasing. While gabapentin and baclofen are less likely than opioids to result in fatal overdose, they are each associated with dependence, misuse and adverse effects.Objective: The objective of this study is to evaluate and describe trends in...
Mehrabadi, Shima Karimiyan, Seyed Morteza Ashabi, Ghorbangol Moradbeygi, Khadijeh Hoseini, Marjan
Published in
Iranian Biomedical Journal
Background: Tolerance and dependence to anti-nociceptive effect of morphine restricted its use. Nowadays co-administration of morphine and other drugs suggests diminishing this tolerance. Baclofen is one of the drugs that may be beneficial in the attenuation of tolerance to morphine. Studies have shown that changes in TRPV-1 expression during admin...
Ketcherside, Ariel Jagannathan, Kanchana Dolui, Sudipto Hager, Nathan Spilka, Nathaniel Nutor, Chaela Rao, Hengyi Franklin, Teresa Wetherill, Reagan
Published in
Clinical Psychopharmacology and Neuroscience
Objective Smoking cue-(SC) elicited craving can lead to relapse in SC-vulnerable individuals. Thus, identifying treatments that target SC-elicited craving is a top research priority. Reduced drug cue neural activity is associated with recovery and is marked by a profile of greater tonic (resting) activation in executive control regions, and increas...
Ibrahim, Mohamed Sarhan, Hatem A Naguib, Youssef W Abdelkader, Hamdy
Published in
International journal of pharmaceutics
Baclofen is a centrally acting skeletal muscle relaxant approved by the US Food and Drug Administration (FDA) for the treatment of muscle spasticity, but the immediate release mode of administration and rapid absorption has been associated with adverse effects. The main objective of this study was to prepare modified release floating beads of baclo...
