Des formes épimastigotes du parasite #Trypanosoma cruzi$ ont été rendues résistantes au benznidazole en utilisant, in vitro, une pression médicamenteuse continue. Les parasites ont été sélectionnés en fonction de la caractérisation génétique antérieure de leurs loci isoenzymatiques. Tous les clones résistants sont capables de croître en culture à l...
Five bisbenzylisoquinoline (BBI) alkaloids, curine, cycleanine, isotetrandrine, limacine and pheanthine were tested for trypanocidal activity in C3H/He mice infected with Y or CL strain of #Trypanosoma cruzi$. The activity was compared with the baseline drug, benznidazole. Oral treatment was more effective with curine at 10 mg/kg or with cycleanine...
We have shown previously that daphnoline and cepharanthine are active against #Trypanosoma cruzi$ and inhibited trypanothione reductase. The effects of oral treatments with daphnoline, cepharanthine and benznidazole were examined in Balb/c mice infected with #T. cruzi$ acutely and chronically. In acute infections, parasitaemia was significantly red...
FAPESP
RenE Berrios Cruz (Cruz Roja Nicaraguense, Nicaragua)
RenE Berrios Cruz (Cruz Roja Nicaraguense, Nicaragua)
