Fournet, AlainRojas de Arias, A.Ferreira, M.E.Nakayama, H.Torres de Ortiz, S.Schinini, A.Samudio, M.Vera de Bilbao, N.Lavault, M.Bonté, F.
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We have shown previously that daphnoline and cepharanthine are active against #Trypanosoma cruzi$ and inhibited trypanothione reductase. The effects of oral treatments with daphnoline, cepharanthine and benznidazole were examined in Balb/c mice infected with #T. cruzi$ acutely and chronically. In acute infections, parasitaemia was significantly red...
Fournet, AlainFerreira, M.E.Rojas de Arias, A.Schinini, A.Nakayama, H.Torres, S.Sanabria, R.Guinaudeau, H.Bruneton, J.
Five bisbenzylisoquinoline (BBI) alkaloids, curine, cycleanine, isotetrandrine, limacine and pheanthine were tested for trypanocidal activity in C3H/He mice infected with Y or CL strain of #Trypanosoma cruzi$. The activity was compared with the baseline drug, benznidazole. Oral treatment was more effective with curine at 10 mg/kg or with cycleanine...