Cucunubá, Zulma M Nouvellet, Pierre Peterson, Jennifer K Bartsch, Sarah M Lee, Bruce Y Dobson, Andrew P Basáñez, Maria-Gloria
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
The World Health Organization's 2020 goals for Chagas disease are (1) interrupting vector-borne intradomiciliary transmission and (2) having all infected people under care in endemic countries. Insecticide spraying has proved efficacious for reaching the first goal, but active transmission remains in several regions. For the second, treatment has m...
García-Huertas, Paola Mejía-Jaramillo, Ana María González, Laura Triana-Chávez, Omar
Published in
Journal of cellular biochemistry
Currently, the only available treatments for Trypanosoma cruzi are benznidazole (Bz) and nifurtimox (Nfx). The mechanisms of action and resistance to these drugs in this parasite are not complete known. In order to identify differentially expressed transcripts between sensitive and resistant parasites, a massive pyrosequencing of the T. cruzi trans...
Requena-Mendez, A Bussion, S Aldasoro, E Jackson, Y Angheben, A Moore, D Pinazo, M-J Gascon, J Munoz, J Sicuri, E
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Background: Chagas disease is currently prevalent in European countries hosting large communities from Latin America. Whether asymptomatic individuals at risk of Chagas disease living in Europe should be screened and treated accordingly is unclear. We performed an economic evaluation of systematic Chagas disease screening of the Latin American popu...
Javier Olivera, M Cucunuba, ZM Arturo Alvarez, C Santiago Nicholls, R
Nifurtimox (NFX) is one of the approved drugs used to treat Chagas disease. Safety profile studies and models on risk factors for treatment interruption in adults are scarce in Latin America. This study evaluated retrospectively the medical records of adult Chagas disease patients treated with NFX between 2007 and 2012 in Bogotá, Colombia. An accel...
Bianchi, F Cucunuba, Z Guhl, F Lorena Gonzalez, N Freilij, H Santiago Nicholls, R David Ramirez, J Montilla, M Carolina Florez, A Rosas, F
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Background Chagas disease is an anthropozoonosis caused by Trypanosoma cruzi. Two drugs are currently used for the etiological treatment of the disease: Nifurtimox (Lampit) and Benznidazole. This study presents a quasi-experimental trial (non-control group) of sixty-two patients who were treated for Chagas disease with Nifurtimox (Lampit), and were...
Gutiérrez, Bessy Muñoz, Christian Osorio, Luis Fehér, Krisztina Illyés, Tünde-Zita Papp, Zsuzsa Kumar, Ambati Ashok Kövér, Katalin E Sagua, Hernán Araya, Jorge E
...
Published in
Bioorganic & medicinal chemistry letters
Aromatic oligovalent glycosyl disulfides and some diglycosyl disulfides were tested against three different Trypanosoma cruzi strains. Di-(β-D-galactopyranosyl-dithiomethylene) benzenes 2b and 4b proved to be the most active derivatives against all three strains of cell culture-derived trypomastigotes with IC50 values ranging from 4 to 11 μM at 37 ...
Matta Guedes, Paulo Marcos Salazar Gutierrez, Fredy Roberto Nascimento, Manuela Sales Lima Adelaide Do-Valle-Matta, Maria Silva, Joao Santana
Chronic chagasic cardiomyopathy affects 20% of Chagas disease patients. At present, Chagas disease chemotherapy uses nitrofurans, benznidazole (Rochagan (R), Rodanil (R), Roche) or nifurtimox (Lampit (R), Bayer). Treatment during acute and recent chronic phases in childhood effects 71.5% and 57.6%, respectively, of parasitological cure. However, in...
Matta Guedes, Paulo Marcos Salazar Gutierrez, Fredy Roberto Nascimento, Manuela Sales Lima Adelaide Do-Valle-Matta, Maria Silva, Joao Santana
Chronic chagasic cardiomyopathy affects 20% of Chagas disease patients. At present, Chagas disease chemotherapy uses nitrofurans, benznidazole (Rochagan (R), Rodanil (R), Roche) or nifurtimox (Lampit (R), Bayer). Treatment during acute and recent chronic phases in childhood effects 71.5% and 57.6%, respectively, of parasitological cure. However, in...
Soares, Chrislaine Oliveira Colli, Walter Bechara, Etelvino Jose Henriques Alves, Maria Julia Manso
INCT Processos Redox em Biomedicina - Redoxoma
Soares, Chrislaine Oliveira Colli, Walter Bechara, Etelvino Jose Henriques Alves, Maria Julia Manso
INCT Processos Redox em Biomedicina - Redoxoma
