Published in Pharmacology & therapeutics
Atherosclerosis is a dynamic and progressive inflammatory process in the intimal layer of large and medium-sized arteries, and it is the major contributor to the atherosclerotic cardiovascular disease (ACVD), the leading cause of death worldwide. In an atherosclerotic plaque, phagocytosis of apoptotic cells occurs through an intricate process desig...
Published in Atherosclerosis
Published in European Radiology
ObjectivesWe aimed to investigate if lesion-specific ischaemia by invasive fractional flow reserve (FFR) can be predicted by an integrated machine learning (ML) ischaemia risk score from quantitative plaque measures from coronary computed tomography angiography (CTA).MethodsIn a multicentre trial of 254 patients, CTA and invasive coronary angiograp...
Published in Medical & Biological Engineering & Computing
To investigate the effect of longitudinal variations of cap thickness and tissue properties on wall stresses and strains along the atherosclerotic stenosis, stenotic plaque models (uniformly thick, distally thickened, homogenous, and distally stiffened) were constructed and subjected to computational stress analyses with due consideration of fluid–...
Published in The International Journal of Cardiovascular Imaging
Previous studies have shown that employing the low dose computed tomography (CT) technique based on low tube potential reduces the radiation dose required for the coronary artery examination protocol. However, low tube potential may adversely influence the CT number of plaque composition. Therefore, we aimed to determine whether quantitative athero...
Published in The International Journal of Cardiovascular Imaging
Coronary computed tomography angiography (CCTA) can provide abundant information about the anatomy of the coronary artery. However, this modality is limited in evaluation of myocardial function. Four-dimensional speckle tracking echocardiography (4DSTE) is a novel and sensitive technique for quantitative evaluation of myocardial deformation. We est...
Published in Korean circulation journal
Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Over the last decade coronary computed tomography angiography (CCTA) has gained wide acceptance as a reliable, cost-effective and non-invasive modality for diagnosis and prognostication of CAD. Use of CCTA is now expanding to characterization of plaque morpholo...
Diplomová práce se zabývá změnou napětí působící v aterosklerotickém plátu při změně křivosti poškozené tepny. V první části je popsána biomechanika tepen a provedena rešerše článků, které se zabývají výpočtem napětí v aterosklerotickém plátu. V další částí je vymodelován parametrický 3D model zakřivené tepny s aterosklerózou a následně je pomocí m...
Published in Journal of cerebrovascular and endovascular neurosurgery
Measurement of the degree of stenosis is not enough to decide on the treatment strategy for patients with carotid stenosis. Plaque morphology examination is needed for such a decision-making. Thus, we evaluated the usefulness of plaque magnetic resonance imaging (MRI) to decide on the modality of treatment for patients with carotid atherosclerotic ...
Published in International Journal of Dynamics and Control
The present study is aimed to investigate the drug transport from a half-embedded drug-eluting stent in presence of atherosclerotic plaque. The luminal drug transport has been modelled by convection–diffusion process, whereas, the transport of free drug within the plaque and healthy tissue by reaction–diffusion process and that of bound drug by rea...
