Chaffey, Laura E Roberti, Annabell Bowman, Amelia O'Brien, Conan Jo Som, Liliana Purvis, Gareth Sd Greaves, David R
Published in
European journal of pharmacology
Inflammation is a driver of human disease and an unmet clinical need exists for new anti-inflammatory medicines. As a key cell type in both acute and chronic inflammatory pathologies, macrophages are an appealing therapeutic target for anti-inflammatory medicines. Drug repurposing - the use of existing medicines for novel indications - is an attrac...
Gu, Xuefeng Yu, Zhongxian Qian, Tianwei Jin, Yiqi Xu, Guoxiong Li, Jiang Gu, Jianfeng Li, Ming Tao, Ke
Published in
Frontiers in Molecular Biosciences
Background: Epidemiological research has demonstrated that there is a connection between lipid metabolism disorder and an increased risk of developing arteriosclerosis (AS) and abdominal aortic aneurysm (AAA). However, the precise relationship between lipid metabolism, AS, and AAA is still not fully understood. The objective of this study was to ex...
Dosh, Laura Ghazi, Maya Haddad, Karim El Masri, Jad Hawi, Jihad Leone, Angelo Basset, Charbel Geagea, Alice Gerges Jurjus, Rosalyn Jurjus, Abdo
...
Published in
Transplant immunology
Cardiovascular diseases (CVD) are one of the most challenging diseases and many factors have been demonstrated to affect their pathogenesis. One of the major factors that affect CVDs, especially atherosclerosis, is the gut microbiota (GM). Genetics play a key role in linking CVDs with GM, in addition to some environmental factors which can be eithe...
Deprez, Louis Kempinaire, Gautier Lorthioir, Félicie Moïse, Martin
L’athérosclérose carotidienne est une des causes les plus fréquentes d’accident ischémique cérébral (AIC). Si la dangerosité d’une plaque d’athérome est historiquement vue uniquement à travers le prisme de la sténose qu’elle engendre, l’évolution des connaissances nous pousse à considérer sa composition à la recherche de facteurs de vulnérabilité. ...
McCue, Ian
The endothelium is the central regulator of all classically understood functions of the vasculature. Decades of research has established that mechanical cues from the blood flow environment induce substantial effects on cell phenotype, and initiate deadly diseases such as atherosclerosis. Our recent work demonstrated that mechanical stimuli like sh...
Bec, Julien Zhou, Xiangnan Villiger, Martin Southard, Jeffrey A Bouma, Brett Marcu, Laura
The clinical management of coronary artery disease and the prevention of acute coronary syndromes require knowledge of the underlying atherosclerotic plaque pathobiology. Hybrid imaging modalities capable of comprehensive assessment of biochemical and morphological plaques features can address this need. Here we report the first implementation of a...
Devineni, Divya Akbarpour, Meleeka Gong, Yufan Wong, Nathan
PURPOSE: Data are limited on sodium glucose co-transport 2 inhibitors (SGLT2-is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) among real-world cohorts of underrepresented patients. We examined these therapies and glycemic control in US adults with diabetes mellitus (DM) by atherosclerotic cardiovascular disease (ASCVD) risk and sociode...
Sung, Jin Young Kim, Seul Gi Kang, Young Jin Park, So-Young Choi, Hyoung Chul
Published in
Biochimica et biophysica acta. Molecular and cell biology of lipids
Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis via lipid-mediated mitochondrial dysfunction and oxidative stress. However, the mechanisms of mitochondrial dysfunction and VSMC senescence in atherosclerosis have not been established. Here, we investigated the mechanisms whereby signaling pathways regulated by SRT1720 enhance ...
Ma, Yun Gu, Tianhe He, Siqi He, Shuya Jiang, Zhisheng
Published in
Molecular and cellular biochemistry
Cardiovascular disease (CVD) has a high incidence and low cure rate worldwide, and atherosclerosis (AS) is the main factor inducing cardiovascular disease, of which lipid deposition in the vessel wall is the main marker of AS. Currently, although statins can be used to lower lipids and low-density lipoprotein (LDL) in AS, the cure rate for AS remai...
Kumarapperuma, Hirushi Wang, Ran Little, Peter J Kamato, Danielle
Published in
Trends in cardiovascular medicine
Cardiovascular diseases (CVD) are the leading cause of mortality worldwide despite an aggressive reduction of traditional cardiovascular risk factors. Underlying inflammatory conditions such as inflammatory bowel disease (IBD) increase the risk of developing CVD. A broad understanding of the underlying pathophysiological processes between IBD and C...
