Borgmann, Kathleen Ghorpade, Anuja
Published in
Neurotoxicity Research
Methamphetamine (METH) use, with and without human immunodeficiency virus (HIV)-1 comorbidity, exacerbates neurocognitive decline. Oxidative stress is a probable neurotoxic mechanism during HIV-1 central nervous system infection and METH abuse, as viral proteins, antiretroviral therapy and METH have each been shown to induce mitochondrial dysfuncti...
San Gil, Rebecca Ooi, Lezanne Yerbury, Justin J. Ecroyd, Heath
Published in
Molecular Neurodegeneration
Protein inclusions are a predominant molecular pathology found in numerous neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington’s disease. Protein inclusions form in discrete areas of the brain characteristic to the type of neurodegenerative disease, and coincide with the death of neurons in that region (e.g. spinal co...
Marchese, Elisa Di Maria, Valentina Samengo, Daniela Pani, Giovambattista Michetti, Fabrizio Geloso, Maria Concetta
Published in
Neurochemical Research
By taking advantage of a “floxed” conditional CREB mutant mouse (CREB1loxP/loxP), in which postnatal deletion of the Creb gene in the forebrain is driven by the calcium/calmodulin-dependent protein kinase II-α gene (Camk2a) promoter (BCKO mice), we here show that selective disruption of CREB function in adult forebrain neurons results, in adult mic...
Mileva, Guergana R. Moyes, Carinna Syed, Shaezeen Bielajew, Catherine
Published in
Neuropsychobiology
Background: Depression is often associated with an increase in hypothalamic-pituitary-adrenal (HPA) axis reactivity and immune response. To investigate this relationship, we examined the consequences of environmental manipulation on the neural correlates of the HPA axis and immune response in an animal model of depression, the Wistar-Kyoto (WKY) ra...
Thuraisingham, R. A.
Published in
Journal of Molecular Neuroscience
The Puri-Li kinetic model is explored here to study the contribution of microglia and astroglia during the pathogenesis of Alzheimer’s disease (AD). This is carried out by solving the Puri-Li model under steady-state conditions. The derived expressions show that both of them play a role in the pathogenesis of AD. Examination of the steady-state sol...
Zorec, Robert Parpura, Vladimir Vardjan, Nina Verkhratsky, Alexej
Published in
Behavioural brain research
Ageing of the central nervous system (CNS) is the major risk factor for Alzheimer's disease (AD), a type of neurodegeneration that is associated with deficits in cognition and memory and clinically manifested as severe senile dementia. Numerous mental processes underline cognition, including attention, producing and understanding language, learning...
Richa, Rashmi Yadawa, Arun Kumar Chaturvedi, Chandra Mohini
Published in
Neurochemistry international
Chronic hyperglycemia (glucotoxicity) is reported to have detrimental effects on various brain functions leading to neurodegenerative changes. However, the effect of hyperglycemia in combination with high nitric oxide (NO) level (reported to be increased during glucotoxicity), on brain functions is not clear yet. The present study was designed to i...
Stenovec, Matjaž Lasič, Eva Božić, Mićo Bobnar, Saša Trkov Stout, Randy F Jr Grubišić, Vladimir Parpura, Vladimir Zorec, Robert
Published in
Molecular neurobiology
In the brain, astrocytes signal to neighboring cells via regulated exocytotic release of gliosignaling molecules, such as brain-derived neurotrophic factor (BDNF). Recent studies uncovered a role of ketamine, an anesthetic and antidepressant, in the regulation of BDNF expression and in the disruption of astrocytic Ca2+ signaling, but it is unclear ...
Bhat, Shahnawaz Ali Goel, Ruby Shukla, Rakesh Hanif, Kashif
Published in
Molecular neurobiology
Neuroinflammation, sustained by astroglial and microglial activation, is the preceding event in neurodegeneration. Various clinical reports showed better neuroprotection by AT1 receptor blockade (ARB) than angiotensin-converting enzyme inhibition (ACEi), but experimental evidences and associated mechanism for this observation are lacking. Therefore...
Kipp, Markus Hochstrasser, Tanja Schmitz, Christoph Beyer, Cordian
Published in
Neuroscience and biobehavioral reviews
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease that shows a female-to-male gender prevalence and alleviation of disease activity during late stage pregnancy. In MS-related animal models, sex steroids ameliorate symptoms and protect from demyelination and neuronal damage. Underlying mechanisms of these protective avenues...
