Zorec, Robert Parpura, Vladimir Vardjan, Nina Verkhratsky, Alexej
Published in
Behavioural brain research
Ageing of the central nervous system (CNS) is the major risk factor for Alzheimer's disease (AD), a type of neurodegeneration that is associated with deficits in cognition and memory and clinically manifested as severe senile dementia. Numerous mental processes underline cognition, including attention, producing and understanding language, learning...
Richa, Rashmi Yadawa, Arun Kumar Chaturvedi, Chandra Mohini
Published in
Neurochemistry international
Chronic hyperglycemia (glucotoxicity) is reported to have detrimental effects on various brain functions leading to neurodegenerative changes. However, the effect of hyperglycemia in combination with high nitric oxide (NO) level (reported to be increased during glucotoxicity), on brain functions is not clear yet. The present study was designed to i...
Stenovec, Matjaž Lasič, Eva Božić, Mićo Bobnar, Saša Trkov Stout, Randy F Jr Grubišić, Vladimir Parpura, Vladimir Zorec, Robert
Published in
Molecular neurobiology
In the brain, astrocytes signal to neighboring cells via regulated exocytotic release of gliosignaling molecules, such as brain-derived neurotrophic factor (BDNF). Recent studies uncovered a role of ketamine, an anesthetic and antidepressant, in the regulation of BDNF expression and in the disruption of astrocytic Ca2+ signaling, but it is unclear ...
Bhat, Shahnawaz Ali Goel, Ruby Shukla, Rakesh Hanif, Kashif
Published in
Molecular neurobiology
Neuroinflammation, sustained by astroglial and microglial activation, is the preceding event in neurodegeneration. Various clinical reports showed better neuroprotection by AT1 receptor blockade (ARB) than angiotensin-converting enzyme inhibition (ACEi), but experimental evidences and associated mechanism for this observation are lacking. Therefore...
Kipp, Markus Hochstrasser, Tanja Schmitz, Christoph Beyer, Cordian
Published in
Neuroscience and biobehavioral reviews
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease that shows a female-to-male gender prevalence and alleviation of disease activity during late stage pregnancy. In MS-related animal models, sex steroids ameliorate symptoms and protect from demyelination and neuronal damage. Underlying mechanisms of these protective avenues...
Clasadonte, Jerome Morel, Lydie Barrios-Camacho, Camila M Chiang, Ming Sum R Zhang, Jinhua Iyer, Lakshmanan Haydon, Philip G Yang, Yongjie
Published in
Neurobiology of disease
Astroglia, the most abundant glial cells in the mammalian central nervous system (CNS), are considered an emerging key player in seizure induction and progression. Although astrocytes undergo reactive gliosis in temporal lobe epilepsy (TLE) with dramatic morphological and molecular changes, specific astrocyte targets/molecular pathways that contrib...
Zendedel, Adib Johann, Sonja Mehrabi, Soraya Joghataei, Mohammad-taghi Hassanzadeh, Gholamreza Kipp, Markus Beyer, Cordian
Published in
Molecular Neurobiology
Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under the control of an intracellular ...
Chu, Chun-Hsien Wang, Shijun Li, Chia-Ling Chen, Shih-Heng Hu, Chih-Fen Chung, Yi-Lun Chen, Shiou-Lan Wang, Qingshan Lu, Ru-Band Gao, Hui-Ming
...
Published in
Brain, behavior, and immunity
Endotoxin tolerance (ET) is a reduced responsiveness of innate immune cells like macrophages/monocytes to an endotoxin challenge following a previous encounter with the endotoxin. Although ET in peripheral systems has been well studied, little is known about ET in the brain. The present study showed that brain immune cells, microglia, being differe...
Muñiz, Javier A. Gomez, Gimena González, Betina Rivero-Echeto, María Celeste Cadet, Jean Lud García-Rill, Edgar Urbano, Francisco J. Bisagno, Veronica
Published in
Neurotoxicity Research
Caffeine is the world’s most popular psychoactive drug and is also an active adulterant found in many drugs of abuse, including seized cocaine samples. Despite several studies which examine the effects of caffeine or cocaine administered as single agents, little data are available for these agents when given in combination. The purpose of the prese...
Gispert, Juan Domingo Monté, Gemma C Falcon, Carles Tucholka, Alan Rojas, Santiago Sánchez-Valle, Raquel Antonell, Anna Lladó, Albert Rami, Lorena Molinuevo, José Luis
...
Published in
Neurobiology of aging
Cerebrospinal fluid (CSF) concentrations of YKL-40 that serve as biomarker of neuroinflammation are known to be altered along the clinico-biological continuum of Alzheimer's disease (AD). The specific structural cerebral correlates of CSF YKL-40 were evaluated across the early stages of AD from normal to preclinical to mild dementia. Nonlinear gray...