Flores-Cuadrado, Alicia Saiz-Sanchez, Daniel Mohedano-Moriano, Alicia Martinez-Marcos, Alino Ubeda-Bañon, Isabel
Published in
Acta Neuropathologica Communications
Parkinson’s disease is characterized by a proteinopathy that includes aggregates of α-synuclein. A recent hypothesis proposes a prion-like spreading mechanism for this α-synucleinopathy. Early neuropathological deposits occur, among others, in the anterior olfactory nucleus (AON). This study investigates the anterograde and/or retrograde transmissi...
Lee, Sooyoung Morioka, Takato Chong, Pin Fee Suzuki, Satoshi O. Imagi, Toru Murakami, Nobuya Baba, Hiroshi Kira, Ryutaro
Published in
Neurological Sciences
Hyperintensity in the subcortical white matter on the diffusion-weighted magnetic resonance image has been described recently, in association with partial status epilepticus. Although this reduced subcortical diffusion is typically seen in patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), the exact pathoph...
Lien, Brian V Tuszynski, Mark H Lu, Paul
Published in
Experimental neurology
Neural stem cells (NSCs) can differentiate into both neurons and glia after transplantation into spinal cord injury (SCI) sites. The neuronal component of stem cell grafts has the potential to form functional synaptic relays across the lesion site. The glial component may reform a blood-spinal cord barrier, support neuronal function, and contribute...
Fields, Jerel Adam Ellis, Ronald J
HIV-associated neurocognitive disorders (HAND) persist in the era of effective combined antiretroviral therapy (cART). A large body of literature suggests that mitochondrial dysfunction is a prospective etiology of HAND in the cART era. While viral load is often suppressed and the immune system remains intact in HIV+ patients on cART, evidence sugg...
Wang, Guo-Qing Zhang, Bei He, Xue-Mei Li, Dai-Di Shi, Jing-Shan Zhang, Feng
Published in
Pharmacological research
Astroglia serve as a critical role in metabolic and neurotrophic support to neurons. The loss of astroglia-derived neurotrophic effects could be a primary contributor to Parkinson's disease (PD). Thus, understanding astroglia functions is an important strategy for enhancing neuronal survival. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays...
Diz-Chaves, Y. Toba, L. Fandiño, J. González-Matías, L. C. Garcia-Segura, L. M. Mallo, F.
Published in
Journal of Neuroinflammation
BackgroundPerinatal maternal malnutrition is related to altered growth of tissues and organs. The nervous system development is very sensitive to environmental insults, being the hippocampus a vulnerable structure, in which altered number of neurons and granular cells has been observed. Moreover, glial cells are also affected, and increased express...
Sekar, Sathiya Mani, Sugumar Rajamani, Barathidasan Manivasagam, Thamilarasan Thenmozhi, Arokiasamy Justin Bhat, Abid Ray, Bipul Essa, Musthafa Mohamed Guillemin, Gilles J. Chidambaram, Saravana Babu
...
Published in
Neurotoxicity Research
Many studies reported the neuroprotective effects of angiotensin II type 1 receptor (AT1R) antagonists in Parkinson’s disease (PD). However, the role of AT1R blockade on astroglial, in turn, dopaminergic functions in chronic PD is still to be studied. In the present study, telmisartan (TEL; 3 and 10 mg/kg/day; p.o), was used to study the effects AT...
Gorojod, Roxana Mayra Alaimo, Agustina Porte Alcon, Soledad Martinez, Jimena Hebe Cortina, María Eugenia Vazquez, Elba Susana Kotler, Mónica Lidia
Published in
Toxicology letters
Heme Oxygenase-1 (HO-1), a stress- responsive enzyme which catalyzes heme degradation into iron, carbon monoxide, and biliverdin, exerts a neuroprotective role involving many different signaling pathways. In Parkinson disease patients, elevated HO-1 expression levels in astrocytes are involved in antioxidant defense. In the present work, employing ...
Granado, Noelia Ares-Santos, Sara Tizabi, Yousef Moratalla, Rosario
Published in
Neurotoxicity Research
Methamphetamine (METH), an amphetamine derivate, may increase the risk of developing Parkinson’s disease (PD). Human and animal studies have shown that METH produces persistent dopaminergic neurotoxicity in the nigrostriatal pathway, despite initial partial recovery. To determine the processes leading to early compensation, we studied the detailed ...
Thuraisingham, R. A.
Published in
Journal of Molecular Neuroscience
The Puri-Li kinetic model is modified to include neuronal calcium ion homeostasis to study the effect of calcium ions on the production of amyloid-β peptides (Aβ), microglia, and astroglia during the pathogenesis of Alzheimer’s disease (AD). This is carried out by solving the modified Puri-Li model under steady-state conditions. The derived express...
