Garcés, Moisés Guijarro, M Isabel Vargas, Antonia Badiola, Juan J Monzón, Marta
Published in
Mechanisms of ageing and development
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are considered prion-like disorders because they are all proteinopathies in which aberrant proteins spread throughout the brain during disease progression. The overall aim of this study is to determine how glial cells are commonly involved in the neurodegeneration progress observed in...
Clarke, Benjamin E Gil, Rebecca San Yip, Jing Kalmar, Bernadett Greensmith, Linda
Published in
Cell stress & chaperones
Preferential neuronal vulnerability is characteristic of several neurodegenerative diseases including the motor neuron disease amyotrophic lateral sclerosis (ALS). It is well established that glia play a critical role in ALS, but it is unknown whether regional differences in the ability of glia to support motor neurons contribute to the specific pa...
Delsing, Louise Kallur, Therése Zetterberg, Henrik Hicks, Ryan Synnergren, Jane
Published in
Fluids and Barriers of the CNS
BackgroundHuman induced pluripotent stem cells (hiPSC) hold great promise for use in cell therapy applications and for improved in vitro models of human disease. So far, most hiPSC differentiation protocols to astroglia use undefined, animal-containing culture matrices. Laminins, which play an essential role in the regulation of cell behavior, offe...
Bollinger, Justin L Salinas, Isabella Fender, Emily Sengelaub, Dale R Wellman, Cara L
Published in
Journal of neuroendocrinology
Women are more susceptible to various stress-linked psychopathologies, including depression. Dysfunction of the medial prefrontal cortex (mPFC) has been implicated in depression, and studies indicate sex differences in stress effects on mPFC structure and function. For example, chronic stress induces dendritic atrophy in the mPFC in male rats, yet ...
Hallett, Penelope J. Engelender, Simone Isacson, Ole
Published in
Journal of Neuroinflammation
This article describes pathogenic concepts and factors, in particular glycolipid abnormalities, that create cell dysfunction and synaptic loss in neurodegenerative diseases. By phenocopying lysosomal storage disorders, such as Gaucher disease and related disorders, age- and dose-dependent changes in glycolipid cell metabolism can lead to Parkinson’...
Draoui, Ahmed El Hiba, Omar Abdelaati, El Khiat Abbaoui, Abdellatif El Fari, Radouane Aitihya, Mohamed Gamrani, Halima
Published in
Brain research bulletin
Studying the non-motor disorders of the prodromal phase of Parkinson's disease (PD) is of great importance because of their negative impact on patient's quality of life. Classical neurotoxic animal models of PD generally unable the exploration of the progression of the non-motor phase of the prodromal stage of the disease. The aim of this study is ...
Smith, Alex J. Duan, Tianjiao Verkman, Alan S.
Published in
Acta Neuropathologica Communications
Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer’s disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to impair bulk Aβ clearance in AD, resulting in increase...
Smith, Alex J Duan, Tianjiao Verkman, Alan S
Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer's disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to impair bulk Aβ clearance in AD, resulting in increase...
Brambilla, Roberta
Published in
Acta Neuropathologica
Neuroinflammation is the coordinated response of the central nervous system (CNS) to threats to its integrity posed by a variety of conditions, including autoimmunity, pathogens and trauma. Activated astrocytes, in concert with other cellular elements of the CNS and immune system, are important players in the modulation of the neuroinflammatory res...
Flores-Cuadrado, Alicia Saiz-Sanchez, Daniel Mohedano-Moriano, Alicia Martinez-Marcos, Alino Ubeda-Bañon, Isabel
Published in
Acta Neuropathologica Communications
Parkinson’s disease is characterized by a proteinopathy that includes aggregates of α-synuclein. A recent hypothesis proposes a prion-like spreading mechanism for this α-synucleinopathy. Early neuropathological deposits occur, among others, in the anterior olfactory nucleus (AON). This study investigates the anterograde and/or retrograde transmissi...
