Funder: European Molecular Biology Laboratory (EMBL); Id: http://dx.doi.org/10.13039/100013060 / Abstract: Adaptive laboratory evolution has proven highly effective for obtaining microorganisms with enhanced capabilities. Yet, this method is inherently restricted to the traits that are positively linked to cell fitness, such as nutrient utilization...
Published in Sexologies
Context Starting with the end of 2019, humanity is fighting a new type of virus, SARS-COV-2, which has brought great changes in people's lives. The COVID-19 pandemic began at the end of 2019 and spread rapidly around the world, affecting the entire planet population. Methods In order to identify the studies on the topic for this meta-analysis, we p...
Indian Citation Index database is a influential tool to pursuit, track, measure and collaborate in the sciences, social sciences, arts, and humanities. This research paper is discussed the published research articles, citations and self-citations in the International Journal of Information Dissemination and Technology which are available in the Ind...
Indian Citation Index database is a authoritative tool to search, track, and measure and collaborate in the sciences, social sciences, arts, and humanities. This paper is discussed the published research articles, citations and self-citations in PEARL : Journal of Library & Information Science which are available in Indian Citation Index. During th...
Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in each of the outcomes to be classed as a responder overall. One instance of this occurs in systemic lupus erythematosus, wher...
Funder: European Molecular Biology Laboratory (EMBL); Id: http://dx.doi.org/10.13039/100013060 / Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer-related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here, we integrated multi-omics data fr...
Individual plant cells possess a genetic network, the circadian clock, that times internal processes to the day-night cycle. Mathematical models of the clock are typically either "whole-plant" that ignore tissue or cell type-specific clock behavior, or "phase-only" that do not include molecular components. To address the complex spatial coordinatio...
Abstract: T cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response, which is hypothesized to depend on T cells combining stimuli from multiple antigen‐presenting cell interactions into a more potent response. To quantify the capacity for T cells to accomplish this, we have developed an ant...
Abstract: This article analyses Francesco Ottieri's historical work, his authority as historian, and his book's eighteenth‐century readers. During the seventeenth century, books concerning recent events and early newspapers informed an expanding European readership. Between 1716 and 1735, Ottieri authored the Istoria, an eight‐volume account of the...
Abstract: Mutations in OPA1 cause autosomal dominant optic atrophy (DOA) as well as DOA+, a phenotype characterized by more severe neurological deficits. OPA1 deficiency causes mitochondrial fragmentation and also disrupts cristae, respiration, mitochondrial DNA (mtDNA) maintenance, and cell viability. It has not yet been established whether phenot...
