The hydration properties of the interface between lipid bilayers and bulk water are important for determining membrane characteristics. Here, the emission properties of a solvent-sensitive fluorescence probe, 6-lauroyl-2-dimethylamino naphthalene (Laurdan), were evaluated in lipid bilayer systems composed of the sphingolipids D-erythro-N-palmitoyl-...
10-Hydroxycamptothecin (HCPT) effectively controls epidural fibrosis, but the exact underlying mechanisms remain ambiguous. Abnormal microRNA (miR)-23b-3p expression has been detected in various types of fibrotic tissues that are present in different diseases. The aim of the present study was to elucidate the mechanisms through which HCPT induces f...
The present study aimed to assess the protective effects of tetramethylpyrazine (TMP) on the livers of mice fed a high fat diet. The mice were divided into five groups: Regular diet; high fat diet; simvastatin-treated; and low and high dose TMP-treated groups. The results demonstrated that, compared with the control group, serum glucose, total chol...
Alzheimer’s disease (AD) is one of the most frequent diseases in elderly people and causes high mortality. Its incidence is increasing annually and no effective therapeutic treatment currently exists. In the present study, salidroside, a major active ingredient of Rhodiola rosea, was able to protect PC-12 cells from the toxicity and apoptosis induc...
Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is a serious complication that occurs several days or weeks after carbon monoxide (CO) intoxication. This study identified computed tomography (CT) findings in the prediction of DEACMP development. Adults with CO poisoning admitted to Beijing Chaoyang Hospital, Shenyang Ninth Peo...
Chemoproteomic approaches to identify ligand-receptor interactions have gained popularity. However, identifying transmembrane receptors remains challenging. A new trifunctional probe to aid the nonbiased identification of such receptors was developed and synthesized using a convenient seven-step synthesis. This probe contained three functional grou...
Published in Statistical methods in medical research
A Bayesian methodology is proposed for constructing a parametric prior on two treatment effect parameters, based on graphical information elicited from a group of expert physicians. The motivating application is a 70-patient randomized trial to compare two treatments for idiopathic nephrotic syndrome in children. The methodology relies on histogram...
Physical Activity (PA) is essential for the prevention of non-communicable diseases (NCD). The risk of developing NCDs is three times as high among people with disabilities than people without disabilities. In 2016, an estimated 158,570 people in Hawai‘i had disabilities. So far, only limited studies have considered increasing PA opportunities for ...
Adipose-derived stem cells (ADSCs) and bone marrow-derived stem cells (BMSCs) are considered to be prospective sources of mesenchymal stromal cells (MSCs), that can be used in cell therapy for atherosclerosis. The present study investigated whether ADSCs co-cultured with M1 foam macrophages via treatment with oxidized low-density lipoprotein (ox-LD...
Patient: Female, 71 Final Diagnosis: Anaplastic thyroid carcinoma Symptoms: Breathlessness Medication: — Clinical Procedure: Total thyroidectomy along with left modified radical neck dissection Specialty: Oncology OBJECTIVE: Unusual clinical course BACKGROUND: Anaplastic thyroid carcinoma (ATC) is an uncommon and aggressive form of human cancer. De...
