Epithelia are tissues made up of cells that are highly adherent to each other. Thanks to this property, epithelia act as a barrier and protect the organs they encase from external dangers such as infections. However, epithelia are far from static and exhibit high rates of cell turnover through cell division and death. This is a challenge for the ti...
La persistance de l’immunité humorale adaptative repose particulièrement sur 2 acteurs clés : les lymphocytes B mémoires et les plasmocytes à longue durée de vie. Indépendamment de la classe d’immunoglobuline produite, ces cellules peuvent maintenir tant la protection contre des pathogènes que des manifestations d’hypersensibilité ou d’immunopathol...
Nutritional interventions are investigated in the context of non-communicable diseases such as cancer. Dietary regimens such as caloric restriction, fasting, ketogenic and protein-restricted diets have shown benefits to control tumor progression. Indeed, we have previously reported the protective effect of an isocaloric diet partially reduced in pr...
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2022. / O carcinoma hepatocelular (CHC) e o glioblastoma (GBM) caracterizam-se pela agressividade relacionada a alterações bioquímicas nos mecanismos de diferenciação, proliferação e morte celular. A busc...
Les tumeurs mammaires triple-négatives (TNBC) représentent 20 % des cancers du sein et leur traitement constitue un enjeu majeur en cancérologie puisque peu de thérapies ciblées efficaces sont actuellement disponible pour les patients. Parmi les TNBC, 77% n'expriment pas la claudine 1 (une protéine des jonctions serrées) et sont appelés tumeurs « c...
Published in Arquivos de neuro-psiquiatria
Characterized by demyelination, inflammation and axonal damage, multiple sclerosis (MS) is one of the most common disorders of central nervous system led by the immune system. There is an urgent and obvious need for biomarkers for the diagnosis and follow-up of MS. To investigate serum levels of sestrin2 (SESN2), a protein that responds to acute st...
Published in Arquivos de neuro-psiquiatria
Multiple sclerosis (MS) is an inflammatory and neurodegenerative autoimmune chronic neurological disease. Currently, there are no effective serum biomarkers to verify MS diagnosis, to assess disease prognosis, and evaluate response to MS treatment. The present study is a preliminary assessment of irisin and nesfatin-1 serum levels in patients with ...
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2022. / Introdução: Considerando terapias anticâncer envolvendo alvos moleculares específicos, compostos miméticos de BH3 podem atuar de modo mais seletivo em células tumorais, minimizando possíveis efeito...
Published in Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia that leads to diabetic nephropathy (DN). We showed that P2X7, a purinergic receptor, was highly expressed in DM; however, when oxidative stress was controlled, renal NO recovered, and the activation of this receptor remained significantly reduced. The aim of this study was t...
En France, 380 000 nouveaux diagnostics de cancer sont posés chaque année et 60% de ces cancers sont traités par radiothérapie. La radiothérapie utilise les rayonnements ionisants pour détruire les cellules tumorales. La radiothérapie engendre des effets radiotoxiques indésirables sur les tissus sains situés dans le champ d’irradiation. Cependant, ...
