Ji, Guangchen Neugebauer, Volker
Published in
Molecular Brain
The amygdala plays an important role in the emotional-affective aspects of behaviors and pain, but can also modulate sensory aspect of pain (“nociception”), likely through coupling to descending modulatory systems. Here we explored the functional coupling of the amygdala to spinal nociception. We found that pharmacological activation of neurons in ...
Bijanki, Kelly R van Rooij, Sanne J H Ely, Timothy D Stevens, Jennifer S Inman, Cory S Fasano, Rebecca E Carter, Sierra E Winters, Sterling J Baman, Justin R Drane, Daniel L
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Published in
Neurosurgery
Post-traumatic stress disorder is a severe psychobiological disorder associated with hyperactivity of the amygdala, particularly on the right side. Highly selective laser ablation of the amygdalohippocampal complex is an effective neurosurgical treatment for medically refractory medial temporal lobe epilepsy that minimizes neurocognitive deficits r...
Park, Jung-Cheol Jeon, Yong-Jae Kim, Jeansok J Cho, Jeiwon Choi, Dong-Hee Han, Jung-Soo
Published in
Neuroscience letters
The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPFC chemical lesions. mPFC-lesion...
Chen, Wen-Bing Pan, Han-Qing He, Ye Wang, Xue-Hui Zhang, Wen-Hua Pan, Bing-Xing
Published in
Cell & Bioscience
BackgroundFear is an adaptive response across species in the face of threatening cues. It can be either innate or learned through postnatal experience. We have previously shown that genetic deletion of both Rap1a and Rap1b, two isoforms of small GTPase Rap1 in forebrain, causes impairment in auditory fear conditioning. However, the specific roles o...
Arioli, Maria Gianelli, Claudia Canessa, Nicola
Published in
Brain imaging and behavior
The possible uniqueness of social stimuli constitutes a key topic for cognitive neuroscience. Growing evidence highlights graded contributions to their semantic processing by the anterior temporal lobe (ATL), where the omni-category response displayed by its ventrolateral sector might reflect the integration of information relayed from other region...
CL, Nord DC, Halahakoon N, Lally T, Limbachya S, Pilling JP, Roiser
Published in
Journal of Affective Disorders
Background Modern cognitive neuropsychological models of depression posit that negatively biased emotional (“hot”) processing confers risk for depression, while preserved executive function (“cold”) cognition promotes resilience. Methods We compared neural responses during hot and cold cognitive tasks in 99 individuals: those at familial risk for d...
Bashwiner, David M Bacon, Donna K Wertz, Christopher J Flores, Ranee A Chohan, Muhammad O Jung, Rex E
Published in
NeuroImage
While the behavior of "being musically creative"- improvising, composing, songwriting, etc.-is undoubtedly a complex and highly variable one, recent neuroscientific investigation has offered significant insight into the neural underpinnings of many of the creative processes contributing to such behavior. A previous study from our research group (Ba...
Durieux, Laura Mathis, Victor Herbeaux, Karine Muller, Marc–Antoine Barbelivien, Alexandra Mathis, Chantal Schlichter, Rémy Hugel, Sylvain Majchrzak, Monique Lecourtier, Lucas
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International audience
Xu, Pengfei Van Dam, Nicholas T van Tol, Marie-José Shen, Xueyi Cui, Zaixu Gu, Ruolei Qin, Shaozheng Aleman, André Fan, Jin Luo, Yue-Jia
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Published in
NeuroImage
Anxious individuals tend to make pessimistic judgments in decision making under uncertainty. While this phenomenon is commonly attributed to risk aversion, loss aversion is a critical but often overlooked factor. In this study, we simultaneously examined risk aversion and loss aversion during decision making in high and low trait anxious individual...
Sullivan, Regina M Opendak, Maya
Published in
Biological psychiatry
Anxiety disorders are the most common form of mental illness and are more likely to emerge during childhood compared with most other psychiatric disorders. While research on children is the gold standard for understanding the behavioral expression of anxiety and its neural circuitry, the ethical and technical limitations in exploring neural underpi...
