Lloyd, William K. Morriss, Jayne Macdonald, Birthe Joanknecht, Karin Nihouarn, Julie van Reekum, Carien M.
Published in
Neuroimage
Networks in the prefrontal cortex (PFC) that are important for executive function are also engaged in adaptive responding to negative events. These networks are particularly vulnerable to age-related structural atrophy and an associated loss of executive function, yet existing evidence suggests preserved emotion processing ability in ageing. Using ...
Fedele, Tommaso Boran, Ece Chirkov, Valerii Hilfiker, Peter Grunwald, Thomas Stieglitz, Lennart Jokeit, Hennric Sarnthein, Johannes
Published in
Scientific Data
Measurement(s) brain electrical activity • response to aversive stimulus • medial temporal lobe • neuronal action potential • functional brain measurement • response to stimulus • amygdalaTechnology Type(s)Electrocorticography • microelectrodeFactor Type(s)aversive vs neutral stimulus • seizure onset zoneSample Characteristic - OrganismHomo sapiens...
Framorando, David Moses, Eleanor Legrand, Lore Seeck, Margitta Pegna, Alan J.
Published in
Scientific Reports
Facial expressions of emotions have been shown to modulate early ERP components, in particular the N170. The underlying anatomical structure producing these early effects are unclear. In this study, we examined the N170 enhancement for fearful expressions in healthy controls as well as epileptic patients after unilateral left or right amygdala rese...
Underwood, Rachel Gannon, Mary Pathak, Aneesh Kapa, Navya Chandra, Sidhanth Klop, Alyssa Yacoubian, Talene A.
Published in
Acta Neuropathologica Communications
Alpha-synuclein (αsyn) is the key component of proteinaceous aggregates termed Lewy Bodies that pathologically define a group of disorders known as synucleinopathies, including Parkinson’s Disease (PD) and Dementia with Lewy Bodies. αSyn is hypothesized to misfold and spread throughout the brain in a prion-like fashion. Transmission of αsyn necessi...
Chin Fatt, Cherise R Cooper, Crystal Jha, Manish K Aslan, Sina Grannemann, Bruce Kurian, Benji Greer, Tracy L Fava, Maurizio Weissman, Myrna McGrath, Patrick J
...
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Major depressive disorder is associated with abnormal connectivity across emotion and reward circuits as well as other established circuits that may negatively impact treatment response. The goal of this study was to perform an exploratory reanalysis of archival data from a clinical trial to identify moderators of treatment outcome of sertraline ov...
Wang, Na Liu, Xing Li, Xin-Tong Li, Xin-Xin Ma, Wei Xu, Yan-Min Liu, Yong Gao, Qing Yang, Tao Wang, Hongxuan
...
Published in
Molecular neurobiology
Alcohol use-associated disorders are highly comorbid with anxiety disorders; however, their mechanism remains unknown. The amygdala plays a central role in anxiety. We recently found that 7,8-dihydroxyflavone (7,8-DHF) significantly reduces withdrawal symptoms in a rat model of chronic intermittent alcohol (ethanol) exposure. This study aimed to de...
Rudolph, Karen D Davis, Megan M Skymba, Haley V Modi, Haina H Telzer, Eva H
Published in
Developmental cognitive neuroscience
The adaptive calibration model suggests exposure to highly stressful or highly supportive early environments sensitizes the brain to later environmental input. We examined whether family and peer experiences predict neural sensitivity to social cues in 85 adolescent girls who completed a social feedback task during a functional brain scan and an in...
Cheng, Theresa W Mills, Kathryn L Miranda Dominguez, Oscar Zeithamova, Dagmar Perrone, Anders Sturgeon, Darrick Feldstein Ewing, Sarah W Fisher, Philip A Pfeifer, Jennifer H Fair, Damien A
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Published in
Developmental cognitive neuroscience
Characterizing typologies of childhood adversity may inform the development of risk profiles and corresponding interventions aimed at mitigating its lifelong consequences. A neurobiological grounding of these typologies requires systematic comparisons of neural structure and function among individuals with different exposure histories. Using seed-t...
Tanaka, Daisuke H Li, Shusheng Mukae, Shiori Tanabe, Tsutomu
Published in
Neuroscience letters
A bitter substance induces specific orofacial and somatic behavioral reactions such as gapes in mice as well as monkeys and humans. These reactions have been proposed to represent affective disgust, and therefore, understanding the neuronal basis of the reactions would pave the way to understand affective disgust. It is crucial to identify and acce...
Fujita, Toshiyuki Aoki, Naoya Mori, Chihiro Fujita, Eiko Matsushima, Toshiya Homma, Koichi J. Yamaguchi, Shinji
Published in
Scientific Reports
Fear is an adaptive emotion that elicits defensive behavioural responses against aversive threats in animals. In mammals, serotonin receptors (5-HTRs) have been shown to modulate fear-related neural circuits in the basolateral amygdala complex (BLA). To understand the phylogenetic continuity of the neural basis for fear, it is important to identify...
