Liu, Ying Deng, ShiJi Zhang, Zhi Gu, Yue Xia, ShengNan Bao, XinYu Cao, Xiang Xu, Yun
Published in
European journal of pharmacology
Neuroinflammation is critical for the pathogenesis of ischemia brain damage. Over-activated microglia-mediated inflammation plays a very important role in ischemia cerebral injuries. 6-Gingerol, obtained from edible ginger (Zingiber Officinale) exhibits protective effects against inflammation. In this study, we found that 6-Gingerol could reduce th...
Kim, Kyung Hwan Kim, Han Sang Kim, Sang Cheol Kim, DooA Kim, Yong Bae Chung, Hyun Cheol Rha, Sun Young
Published in
Frontiers in Oncology
Background Despite the important role of radiotherapy in cancer treatment, a subset of patients responds poorly to treatment majorly due to radioresistance. Particularly the role of radiotherapy has not been established in gastric cancer (GC). Herein, we aimed to identify a radiosensitivity gene signature and to discover relevant targets to enhance...
Rosell, Rafael Filipska, Martyna Chaib, Imane Lligé, David Laguia, Fernando
Published in
Frontiers in oncology
Lee, Eun Hye Chun, So Young Kim, Bomi Yoon, Bo Hyun Lee, Jun Nyung Kim, Bum Soo Yoo, Eun Sang Lee, Sangkyu Song, Phil Hyun Kwon, Tae Gyun
...
Published in
BMC Urology
BackgroundBladder cancer (BC) is one of the most common malignancies of the urinary tract. The role of transient receptor potential melastatin 7 (TRPM7) in BC remains unclear. The aim of this study was to investigate the function and signal transduction pathway of TRPM7 in BC.MethodsT24 and UMUC3 cells were used to evaluate the molecular mechanism ...
Mirkheshti, Alireza Shakeri, Alireza Memary, Elham Baniasadi, Mansoureh Zaringhalam, Jalal Tajbakhsh, Ardeshir Mirzaei, Marzieh Lak, Elena
Published in
BMC Anesthesiology
BackgroundBupivacaine, an amid-type local anesthetic, is widely used for clinical patients especially in pregnant women. In addition to neurotoxicity effect of bupivacaine, it can cross the placenta, accumulates in this tissue and retained in fetal tissues. Nevertheless, whether bupivacaine can cause neurotoxicity in fetus remains unclear. Hence, t...
Chang, Long Zhu, Liqian
Published in
Journal of veterinary science
Fenbendazole, a dewormer drug, is used widely in the clinical treatment of parasite infections in animals. Recent studies have shown that fenbendazole has substantial effects on tumor growth, immune responses, and inflammatory responses, suggesting that fenbendazole is a pluripotent drug. Nevertheless, the antiviral effects have not been reported. ...
Fu, Wenxiang Hall, Michael N.
Published in
Genes
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally di...
Zhao, Li-Dong Bie, Lian-Yu Hu, Lan Zhu, Zi-Han Meng, Xing-Hua Cong, Lin-Lin Zhang, Shai Ma, Ning Xiao, Jian-Hua
Published in
Experimental and Therapeutic Medicine
Cellular senescence decreases cell proliferation over time and is characterized by typical markers, including larger cell volume, a flattened morphology, irreversible cell cycle arrest, augmentation of senescence-associated β-galactosidase (SA-β-gal) activity and senescence-associated secretory phenotype. A variety of factors are implicated in the ...
Ramachandran, Sharavan Srivastava, Sanjay K.
Published in
Molecular Therapy Oncolytics
Drug repurposing, a unique drug developmental strategy, can overcome the pitfalls for pancreatic cancer treatment. In this study, we discover the anticancer effects of an antipsychotic drug, pimavanserin, for pancreatic cancer. Our pre-clinical findings suggest that pimavanserin could be translated into the clinic to improve the treatment outcome o...
Lopez-Bergami, Pablo Barbero, Gastón
Published in
Cancer metastasis reviews
Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its overexpression has been implicated in the progression of several tumor types by promoting cell motility, invasion, EMT, and metastasis. Recent evidences have revealed a novel role of Wnt5a in the phosphorylation of the NF-κB subunit p65 and the activation of the NF-κB pa...
