Li, Yuqin Lu, Xiaolan Tian, Peiying Wang, Kai Shi, Jianping
Published in
BMC Complementary Medicine and Therapies
Background Procyanidin B2 (PB2), a unique component of the grape seed and other medicinal plants. PB2 has shown wide anticancer activity in various human cancer cells. However, it remains unclear about the biological effects and associated mechanisms of PB2 on gastric cancer cells. Methods Cell proliferation was measured by CCK8 assay, and cellular...
Li, Tingting Li, Jiangbing Li, Tong Zhao, Yijing Ke, Hongfei Wang, Shuanglian Liu, Dexiang Wang, Zhen
Published in
Drug Design, Development and Therapy
Background Previous work within our laboratory has revealed that hydrogen sulfide (H2S) can serve as neuroprotectant against brain damage caused by hypoxia-ischemia (HI) exposure in neonatal mice. After HI insult, activation of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway has been shown to be implicated in neuro...
Sui, Xinbing Han, Xuemeng Chen, Peng Wu, Qibiao Feng, Jiao Duan, Ting Chen, Xiaying Pan, Ting Yan, Lili Jin, Ting
...
Published in
Frontiers in Molecular Biosciences
Baicalin, as a natural active ingredient extracted and isolated from the traditional Chinese medicine Scutellaria baicalensis Georgi., has been potentially used in various areas for its antioxidative, antitumor, anti-inflammatory, and anti-proliferative activities. Although several studies have reported the antitumor effects of baicalin against var...
Abdullah, Leena Hills, L. Benjamin Winter, Evan B. Huang, Yina H.
Published in
Immunometabolism
Akt kinases translate various external cues into intracellular signals that control cell survival, proliferation, metabolism and differentiation. This review discusses the requirement for Akt and its targets in determining the fate and function of T cells. We discuss the importance of Akt at various stages of T cell development including β-selectio...
Theodossiou, Sophia K. Murray, Jett B. Hold, LeeAnn A. Courtright, Jeff M. Carper, Anne M. Schiele, Nathan R.
Published in
Stem Cell Research & Therapy
BackgroundTissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members of the transforming growth factor (TGF) β family, particularly TGFβ2, play a role in tenogenesis, which may proceed via Smad-mediat...
Song, Guanjun Huang, Yun Xiong, Mingrui Yang, Ziwei Liu, Qinghua Shen, Jinhua Zhao, Ping Yang, Xinzhou
Published in
Frontiers in Pharmacology
Aloperine (ALO), a quinolizidine alkaloid isolated from Sophora alopecuroides L. used in the traditional Uygur medicine, induced a significant increase in cellular glucose uptake of L6 cells, suggesting it has the potential to relieve hyperglycemia. Therefore, we investigated the effects of ALO on type 2 diabetes mellitus (T2DM) through in vitro an...
Gorur, Aysegul Bayraktar, Recep Ivan, Cristina Mokhlis, Hamada Ahmed Bayraktar, Emine Kahraman, Nermin Karakas, Didem Karamil, Selda Kabil, Nashwa N. Kanlikilicer, Pinar
...
Published in
Molecular Therapy. Nucleic Acids
Our study demonstrates that microRNA-22-3p (miR-22-3p) acts as a tumor suppressor in which its expression is markedly reduced in TNBC tumors. Restoration of its expression by miR-22-3p nanotherapy suppress tumor growth and progression by directly inhibiting of eEF2K-PI3K/AKT and Src signaling. miR-22-3p-based RNA therapy may be novel treatment for ...
Tokinoya, Katsuyuki Sekine, Nanami Aoki, Kai Ono, Seiko Kuji, Tomoaki Sugasawa, Takehito Yoshida, Yasuko Takekoshi, Kazuhiro
Published in
Molecular Medicine Reports
Progression of nonalcoholic steatohepatitis (NASH) is attributed to several factors, including inflammation and oxidative stress. In recent years, renalase has been reported to suppress oxidative stress, apoptosis and inflammation. A number of studies have suggested that renalase may be associated with protecting the liver from injury. The present ...
Monti, Noemi Masiello, Maria Grazia Proietti, Sara Catizone, Angela Ricci, Giulia Harrath, Abdel Halim Alwasel, Saleh H. Cucina, Alessandra Bizzarri, Mariano
Published in
International Journal of Molecular Sciences
Metazoan living cells exposed to microgravity undergo dramatic changes in morphological and biological properties, which ultimately lead to apoptosis and phenotype reprogramming. However, apoptosis can occur at very different rates depending on the experimental model, and in some cases, cells seem to be paradoxically protected from programmed cell ...
Zhao, Helen Lin, Jonathan Sieck, Gary Haddad, Gabriel G.
Published in
Frontiers in Neuroscience
Chronic mountain sickness (CMS) is a disease that potentially threatens a large segment of high-altitude populations during extended living at altitudes above 2,500 m. Patients with CMS suffer from severe hypoxemia, excessive erythrocytosis and neurologic deficits. The cellular mechanisms underlying CMS neuropathology remain unknown. We previously ...
