Lawrence, Marcus M Zwetsloot, Kevin A Arthur, Susan T Sherman, Chase A Huot, Joshua R Badmaev, Vladimir Grace, Mary Lila, Mary Ann Nieman, David C Shanely, R Andrew
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Published in
International journal of environmental research and public health
Skeletal muscle mass and strength are lost with aging. Phytoecdysteroids, in particular 20-hydroxyecdysone (20E), increase protein synthesis in C2C12 skeletal muscle cells and muscle strength in young rats. The objective of this study was to determine whether an extract from Ajuga turkestanica (ATE), enriched in phytoecdysteroids, and 20E affect sk...
Baffi, Timothy R. Cohen-Katsenelson, Ksenya Newton, Alexandra C.
Whereas protein kinases have been successfully targeted for a variety of diseases, protein phosphatases remain an underutilized therapeutic target, in part because of incomplete characterization of their effects on signaling networks. The pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP) is a relatively new player in the ce...
Tong, Samuel J Wall, Adam A Hung, Yu Luo, Lin Stow, Jennifer L
Published in
Small GTPases
Macrophages are important immune sentinels that detect and clear pathogens and initiate inflammatory responses through the activation of surface receptors, including Toll-like receptors (TLRs). Activated TLRs employ complex cellular trafficking and signalling pathways to initiate transcription for inflammatory cytokine programs. We have previously ...
Han, Haote Yang, Yanhui Wu, Zhipan Liu, Bing Dong, Lijun Deng, Hongwei Tian, Jingkui Lei, Hetian
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Abnormal angiogenesis is associated with intraocular diseases such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, and current therapies for these eye diseases are not satisfactory. The purpose of this study was to determine whether capilliposide B (CPS-B), a novel oleanane triterpenoid saponin derived from L...
Wu, Wenyi Xia, Xiaobo Tang, Luosheng Yao, Fei Xu, Huizuo Lei, Hetian
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Vitreous has been reported to prevent tumor angiogenesis, but our previous findings indicate that vitreous activate the signaling pathway of phosphoinositide 3-kinase (PI3K)/Akt, which plays a critical role in angiogenesis. The goal of this research is to determine which role of vitreous plays in angiogenesis-related cellular responses in vitro. We...
Wei, Zhengping Du, Qiuyang Li, Pingfei Liu, Huicheng Xia, Minghui Chen, Yufei Bi, Guoyu Tang, Zhao-Hui Cheng, Xiang Lu, Youming
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Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Appropriate migration of cytotoxic T effector cells into the tumors is crucial for their antitumor function. Despite the controversial role of PI3K-Akt in CD8+ T cell mTORC1 activation, a link between Akt-mTORC1 signaling and CD8+ trafficking has been demonstrated. We have recently discovered that TCR-induced calcineurin activates DAPK1, which inte...
Kao, Ching-Chieh Kung, Po-Hsiung Tai, Chi-Jung Tsai, Meng-Chun Cheng, Yuan-Bin Wu, Chin-Chung
Published in
Phytomedicine : international journal of phytotherapy and phytopharmacology
Juglone, a natural compound widely found in Juglandaceae plants, has been suggested as a potential drug candidate for treating cancer, inflammation, and diabetic vascular complications. In the present study, the antiplatelet effect and underlying mechanisms of juglone were investigated for the first time. Human platelet aggregation and activation w...
Yu, Jimin Cho, Eunbi Kwon, Huiyoung Jeon, Jieun Seong Sin, Jae Kwon Park, Jun Kim, Ji-Su Woong Choi, Ji Jin Park, Se Jun, Mira
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Published in
Biochemical pharmacology
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by memory deficits. Although no drug has given promising results, synaptic dysfunction-modulating agents might be considered potential candidates for alleviating this disorder. Pinoresinol, a lignan found in Forsythia suspensa, is a memory-enhancing agen...
Ishizuka, Toshiaki Nagata, Wataru Nomura-Takahashi, Sayaka Satoh, Yasushi
Published in
European journal of pharmacology
In Alzheimer's disease (AD), a decline in function of neural progenitor cells (NPCs) results in a reduced capacity for neural regeneration. It has been shown that plasma oxidized low-density lipoprotein (ox-LDL) levels are positively correlated with severity in patients with AD. However, the direct effects of ox-LDL on NPCs are unknown. Thus, we ex...
Curtis, David Bandyopadhyay, Sreejan
Published in
Annals of human genetics
A variety of findings from in vitro experiments and animal models support the hypothesis that one contribution to pathogenesis in Alzheimer's disease (AD) is enhanced phosphorylation of tau protein, which may be triggered by amyloid β (Aβ) and mediated by impaired activity of the PI3K/Akt signaling pathway. A number of tyrosine phosphatases act to ...
