Iijima, Hirotaka Gilmer, Gabrielle Wang, Kai Sivakumar, Sruthi Evans, Christopher Matsui, Yusuke Ambrosio, Fabrisia
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Increased mechanistic insight into the pathogenesis of knee osteoarthritis (KOA) is needed to develop efficacious disease-modifying treatments. Though age-related pathogenic mechanisms are most relevant to the majority of clinically presenting KOA, the bulk of our mechanistic understanding of KOA has been derived using surgically induced posttrauma...
Wada, Nikolas I Breen, Elizabeth C Post, Wendy S Stosor, Valentina Macatangay, Bernard J Margolick, Joseph B
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
C-reactive protein (CRP) is an inflammatory biomarker associated with all-cause mortality and morbidities such as cardiovascular disease. CRP is increased with HIV infection and thought to increase with age, though trajectories of CRP with aging have not been well characterized. We investigated trajectories of CRP in men from the Multicenter AIDS C...
Karmacharya, Isha Ghimire, Saruna Bhujel, Kshitiz Shrestha Dhauvadel, Asmita Adhikari, Shraddha Baral, Subash Shrestha, Naveen
Published in
Journal of aging & social policy
The Government of Nepal provides a range of welfare schemes to senior citizens, but little is known about the use of public benefits by older adults. This community-based cross-sectional survey thus aims to assess the utilization and correlates of health services (through both private and public health facilities), free essential health services (p...
Giovannini, Silvia Biscetti, Federico Brau, Fabrizio Biscotti, Lorenzo Santoliquido, Angelo Pitocco, Dario Bernabei, Roberto Flex, Andrea
Published in
Mechanisms of ageing and development
The role of sortilin and omentin-1 in the pathogenesis of atherosclerosis and vascular disease is an emerging topic in recent years. These molecules can be found circulating in the blood. Recent studies have shown how these biomarkers appear to correlate with the severity of PAD. The levels of these molecules appear to be inversely proportional to ...
Guo, Yan Chomiak, Alison A Hong, Ye Lowe, Clara C Kopsidas, Caroline A Chan, Wen-Ching Andrade, Jorge Pan, Hongna Zhou, Xiaoming Monuki, Edwin S
...
Aging is an intricate process characterized by multiple hallmarks including stem cell exhaustion, genome instability, epigenome alteration, impaired proteostasis, and cellular senescence. Whereas each of these traits is detrimental at the cellular level, it remains unclear how they are interconnected to cause systemic organ deterioration. Here we s...
Thomas, Michael L Palmer, Barton W Lee, Ellen E Liu, Jinyuan Daly, Rebecca Tu, Xin M Jeste, Dilip V
Published in
International psychogeriatrics
Wisdom is a personality trait comprising seven components: self-reflection, pro-social behaviors, emotional regulation, acceptance of diverse perspectives, decisiveness, social advising, and spirituality. Wisdom, a potentially modifiable trait, is strongly associated with well-being. We have published a validated 28-item San Diego Wisdom Scale, the...
Vezza, Teresa Díaz-Pozo, Pedro Canet, Francisco de Marañón, Aranzazu M Abad-Jiménez, Zaida García-Gargallo, Celia Roldan, Ildefonso Solá, Eva Bañuls, Celia López-Domènech, Sandra
...
Published in
The world journal of men's health
Mitochondrial dynamics, such as fusion and fission, play a critical role in maintaining cellular metabolic homeostasis. The molecular mechanisms underlying these processes include fusion proteins (Mitofusin 1 [MFN1], Mitofusin 2 [MFN2], and optic atrophy 1 [OPA1]) and fission mediators (mitochondrial fission 1 [FIS1] and dynamin-related protein 1 [...
Endicott, S Joseph Monovich, Alexander C Huang, Eric L Henry, Evelynn I Boynton, Dennis N Beckmann, Logan J MacCoss, Michael J Miller, Richard A
Published in
Autophagy
Mice deficient in GHR (growth hormone receptor; ghr KO) have a dramatic lifespan extension and elevated levels of hepatic chaperone-mediated autophagy (CMA). Using quantitative proteomics to identify protein changes in purified liver lysosomes and whole liver lysates, we provide evidence that elevated CMA in ghr KO mice downregulates proteins invol...
Paolillo, Emily W Saloner, Rowan Kohli, Maulika Watson, C Wei-Ming Moore, Raeanne C Heaton, Robert K Moore, David J
ObjectiveGiven the aging population of people with HIV (PWH), along with increasing rates of binge drinking among both PWH and the general older adult population, this study examined the independent and interactive effects of HIV, binge drinking, and age on neurocognition.MethodParticipants were 146 drinkers stratified by HIV and binge drinking sta...
Asken, Breton M VandeVrede, Lawren Rojas, Julio C Fonseca, Corrina Staffaroni, Adam M Elahi, Fanny M Lindbergh, Cutter A Apple, Alexandra C You, Michelle Weiner-Light, Sophia
...
Published in
Journal of the International Neuropsychological Society : JINS
There are minimal data directly comparing plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in aging and neurodegenerative disease research. We evaluated associations of plasma NfL and plasma GFAP with brain volume and cognition in two independent cohorts of older adults diagnosed as clinically normal (CN), mild cognitive ...
