Nomura, M Sakitani, N Iwasawa, H Kohara, Y Takano, S Wakimoto, Y Kuroki, H Moriyama, H
Published in
Osteoarthritis and cartilage
Thinning of articular cartilage induced by mechanical unloading may be mediated by metabolic changes in chondrocytes, including accelerated aggrecan catabolism and exquisitely modulated matrix mineralization, and cartilage matrix degradation and resorption by subchondral osteoclasts. Cartilage degeneration without chondrocyte hypertrophy under unlo...
Tola, Esra Nur Karatopuk, Dilek Ulusoy Koroglu, Nadiye Ergin, Merve Oral, Hilmi Baha
Published in
Journal of Assisted Reproduction and Genetics
PurposePolycystic ovary syndrome (PCOS) is the most common cause of ovulatory dysfunction and female infertility. The etiopathogenetic mechanisms of PCOS have been studied for many years, although exact causes remain unclear. It has been demonstrated that proteoglycan degradation by a disintegrin-like metalloproteinase with thrombospondin type moti...
Kobayashi, Takashi Kakizaki, Ikuko Nozaka, Hiroyuki Nakamura, Toshiya
Published in
Biochemistry and biophysics reports
Because cartilage lacks nerves, blood vessels, and lymphatic vessels, it is thought to contain factors that inhibit the growth and development of those tissues. Chondroitin sulfate proteoglycans (CSPGs) are a major extracellular component in cartilage. CSPGs contribute to joint flexibility and regulate extracellular signaling via their attached gly...
Deng, Yu Tan, Xin-Ti Wu, Qiang Wang, Xin
Published in
Genetic testing and molecular biomarkers
This case-control study was designed to evaluate the association of three COL2A1 single nucleotide polymorphism (SNPs) (rs1793953, rs2276454, and rs1793937) and Aggrecan variable number of tandem repeat (VNTR) polymorphisms with the risk and clinicopathological features of intervertebral disc degeneration (IVDD) in a Chinese Han population. Data fr...
Wang, Zili Hutton, William C. Yoon, S. Tim
Published in
European Spine Journal
PurposeAn in vitro study using human intervertebral disc nucleus pulposus cells to evaluate the effects of CC stimulation on disc-matrix macromolecule production.MethodsNucleus pulposus cells were cultured in alginate beads and treated with CC stimulation. The effect of BMP on CC stimulation of the cells was evaluated by applying a BMP blocker (nog...
Huang, Yi Askew, Emily B Knudson, Cheryl B Knudson, Warren
Published in
Matrix biology : journal of the International Society for Matrix Biology
Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies have suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to cell-associated HA. However, reagents used to test these observations such as hyaluronidase and HA oligosaccharides are short term ...
Bartz, Christoph Meixner, Miriam Giesemann, Petra Roël, Giulietta Bulwin, Grit-Carsta Smink, Jeske J.
Published in
Journal of Translational Medicine
BackgroundCell-based therapies such as autologous chondrocyte implantation are promising therapeutic approaches to treat cartilage defects to prevent further cartilage degeneration. To assure consistent quality of cell-based therapeutics, it is important to be able to predict the biological activity of such products. This requires the development o...
Van Nieuwenhove, Ine Salamon, Achim Peters, Kirsten Graulus, Geert-Jan Martins, José C Frankel, Daniel Kersemans, Ken De Vos, Filip Van Vlierberghe, Sandra Dubruel, Peter
...
Published in
Carbohydrate polymers
The present work aims at constructing the ideal scaffold matrix of which the physico-chemical properties can be altered according to the targeted tissue regeneration application. Ideally, this scaffold should resemble the natural extracellular matrix (ECM) as close as possible both in terms of chemical composition and mechanical properties. Therefo...
Li, Nianhu Whitaker, Camden Xu, Zhanwang Heggeness, Michael Yang, Shang-You
Published in
The spine journal : official journal of the North American Spine Society
Naringin effectively promotes the proliferation of degenerative human NP cells and improves the recuperation of the cells from degeneration by increasing expression of aggrecan, BMP-2, and Sox6 while inhibiting the expression of TNF-α and MMP3. This study suggests that naringin may represent an alternative therapeutic agent for disc degeneration.
Li, Nianhu Whitaker, Camden Xu, Zhanwang Heggeness, Michael Yang, Shang-You
Published in
The spine journal : official journal of the North American Spine Society
Naringin effectively promotes the proliferation of degenerative human NP cells and improves the recuperation of the cells from degeneration by increasing expression of aggrecan, BMP-2, and Sox6 while inhibiting the expression of TNF-α and MMP3. This study suggests that naringin may represent an alternative therapeutic agent for disc degeneration.
