Zhang, Bin Guo, Wei Sun, Chao Duan, Hui-Quan Yu, Bing-Bing Mu, Kun Guan, Yue-Yan Li, Yan Liu, Shen Liu, Yang
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Published in
Cellular Physiology and Biochemistry
Background/Aims: Low back pain has become one of the most common musculoskeletal diseases in the world. Studies have shown that intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the mechanisms underlying IDD remain largely unknown. Research over the past decade has suggested critical roles for microRNAs (mi...
Eskici, Nazli F. Erdem-Ozdamar, Sevim Dayangac-Erden, Didem
Published in
Cellular & Molecular Biology Letters
BackgroundPerineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteoglycan link protein 1 (HAPLN1), tenascin-R (TNR) and aggrecan (ACAN) are key elements of PNNs. In diseases characterized by neurito...
Rambeau, Pierre Faure, Emilie Theron, Alexis Avierinos, Jean-François Jopling, Chris Zaffran, Stéphane Faucherre, Adèle
Available online xxxx Hemodynamic forces have been known for a long time to regulate cardiogenic processes such as cardiac valve development. During embryonic development in vertebrates, the outflow tract (OFT) adjacent to the ventricle comes under increasing hemodynamic load as cardiogenesis proceeds. Consequently, extracellular matrix components ...
Craddock, Russell James
Collagen II and the proteoglycan aggrecan are key extracellular matrix (ECM) proteins in cartilaginous tissues such as the intervertebral disc (IVD). Given the functional role that these structural and functional proteins have in the IVD, ECM in tissue engineered intervertebral disc (TE IVD) constructs needs to recapitulate native tissue. As such, ...
Tola, Esra Nur Koroglu, Nadiye Dugan Yalcin, Serenat Eris Oral, Hilmi Baha
Published in
Archives of Gynecology and Obstetrics
PurposeThe aim of this study was to analyze serum a disintegrin-like and metalloproteinase with thrombospondin-type motifs-1 (ADAMTS-1) and aggrecan levels in adolescents and younger-aged females with polycystic ovary syndrome (PCOS) compared with ovulatory controls to determine whether these are potential markers for the prediction of PCOS diagnos...
Bricca, A Juhl, C B Grodzinsky, A J Roos, E M
Published in
Osteoarthritis and cartilage
Our results suggest that the relationship between daily exercise dose and cartilage composition, but not necessarily cartilage thickness, may be non-linear. While we found inconclusive evidence for a low daily dose of exercise, a high daily dose of exercise may have negative effects and a moderate daily dose of exercise may have positive effects on...
Liu, Zhuochao Li, Changwei Meng, Xiangchao Bai, Yunting Qi, Jin Wang, Jun Zhou, Qi Zhang, Weibin Zhang, Xingkai
Published in
Biochemical and biophysical research communications
Although hypoxia-inducible factor-lα (HIF-lα) has been reported to have an important role in the metabolism and synthesis of the extracellular matrix (ECM) of nucleus pulposus cells (NPCs), the underlying mechanism has not been fully clarified. Here, we show for the first time that NOTCH1 expression is decreased in NPs isolated from degenerated hum...
Dateki, Sumito Nakatomi, Akiko Watanabe, Satoshi Shimizu, Hitomi Inoue, Yukiko Baba, Hideo Yoshiura, Koh-ichiro Moriuchi, Hiroyuki
Aggrecan is a critical proteoglycan component of the extracellular matrix of the growth plates and articular cartilage and has a key role in the biophysical and biomechanical properties of cartilage. Recently, heterozygous mutations in the ACAN gene, which encodes aggrecan, have been identified in patients with short stature and accelerated bone ag...
Cięszczyk, P Willard, K Gronek, P Zmijewski, P Trybek, G Gronek, J Weber-Rajek, M Stastny, P Petr, M Lulińska-Kuklik, E
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Published in
Biology of sport
Proteoglycans are considered integral structural components of tendon and ligament and have been implicated in the resistance of compressive forces, collagen fibrillogenesis, matrix remodelling and cell signalling. Several sequence variants within genes encoding proteoglycans were recently implicated in modulating anterior cruciate ligament rupture...
Nomura, M Sakitani, N Iwasawa, H Kohara, Y Takano, S Wakimoto, Y Kuroki, H Moriyama, H
Published in
Osteoarthritis and cartilage
Thinning of articular cartilage induced by mechanical unloading may be mediated by metabolic changes in chondrocytes, including accelerated aggrecan catabolism and exquisitely modulated matrix mineralization, and cartilage matrix degradation and resorption by subchondral osteoclasts. Cartilage degeneration without chondrocyte hypertrophy under unlo...
