Rosadi, Imam Karina, Karina Rosliana, Iis Sobariah, Siti Afini, Irsyah Widyastuti, Tias Barlian, Anggraini
Published in
Stem Cell Research & Therapy
BackgroundCartilage tissue engineering is a promising technique for repairing cartilage defect. Due to the limitation of cell number and proliferation, mesenchymal stem cells (MSCs) have been developed as a substitute to chondrocytes as a cartilage cell-source. This study aimed to develop cartilage tissue from human adipose-derived stem cells (ADSC...
Shi, Jinhui Zhou, Xichao Wang, Zhen Kurra, Swamy Niu, Junjie Yang, Huilin
Published in
BMC Musculoskeletal Disorders
BackgroundDegenerative intervertebral disc (IVD) disease can cause lower back pain. However, the change of lactic acid content during disc degeneration process still unclear. The objective of this study was to investigate whether the change of the content of lactic acid is associated with depletion of degenerative intervertebral disc extracellular ...
Szegeczki, Vince Bauer, Balázs Jüngling, Adél Fülöp, Balázs Daniel Vágó, Judit Perényi, Helga Tarantini, Stefano Tamás, Andrea Zákány, Róza Reglődi, Dóra
...
Published in
GeroScience
Pituitary adenylate cyclase activating polypeptide (PACAP) is an evolutionarly conserved neuropeptide which is produced by various neuronal and non-neuronal cells, including cartilage and bone cells. PACAP has trophic functions in tissue development, and it also plays a role in cellular and tissue aging. PACAP takes part in the regulation of chondr...
Novais, Emanuel J Diekman, Brian O Shapiro, Irving M Risbud, Makarand V
Published in
Matrix biology : journal of the International Society for Matrix Biology
Intervertebral disc degeneration is an important contributor to chronic low back and neck pain. Although many environmental and genetic factors are known to contribute to disc degeneration, age is still the most significant risk factor. Recent studies have shown that senescence may play a role in age-related disc degeneration and matrix catabolism ...
Widmer, Steven Steiner, Richard P Morscher, Melanie A Shasti, Mark Weiner, Dennis S Adamczyk, Mark J Childs, Robin DiFeo Landis, William J
Control tissue in studies of various orthopedic pathologies is difficult to obtain and presumably equivalent biopsies from other anatomic sites have been utilized in its place. However, for growth plates, different anatomic regions are subject to dissimilar mechanical forces and produce disproportionate longitudinal growth. The purpose of this stud...
Widmer, Steven Steiner, Richard P Morscher, Melanie A Shasti, Mark Weiner, Dennis S Adamczyk, Mark J Childs, Robin DiFeo Landis, William J
Published in
Bone reports
Control tissue in studies of various orthopedic pathologies is difficult to obtain and presumably equivalent biopsies from other anatomic sites have been utilized in its place. However, for growth plates, different anatomic regions are subject to dissimilar mechanical forces and produce disproportionate longitudinal growth. The purpose of this stud...
Vaca González, Juan Jairo
Tesis por compendio / [ES] El cartílago hialino es un tejido conectivo denso con poca capacidad de auto regeneración cuando es afectado por patologías degenerativas. Por lo tanto, la estimulación eléctrica se ha propuesto como una terapia alternativa no invasiva para mejorar la reparación del cartílago hialino. De acuerdo con esto, este trabajo pre...
Knudson, Warren Ishizuka, Shinya Terabe, Kenya Askew, Emily B Knudson, Cheryl B
Published in
Matrix biology : journal of the International Society for Matrix Biology
The story of hyaluronan in articular cartilage, pericellular hyaluronan in particular, essentially is also the story of aggrecan. Without properly tethered aggrecan, the load bearing function of cartilage is compromised. The anchorage of aggrecan to the cell surface only occurs due to the binding of aggrecan to hyaluronan-with hyaluronan tethered e...
Terabe, Kenya Takahashi, Nobunori Cobb, Michelle Askew, Emily B Knudson, Cheryl B Knudson, Warren
Published in
Archives of biochemistry and biophysics
In this study we examined whether the action of simvastatin affects re-differentiation of passaged chondrocytes and if so, whether this was mediated via changes in cholesterol or cholesterol intermediates. Bovine articular chondrocytes, of varying passage number, human knee chondrocytes and rat chondrosarcoma chondrocytes were treated with simvasta...
Kim, Sang-Min Huh, Jae-Wan Kim, Eun-Young Shin, Min-Kyung Park, Ji-Eun Kim, Seong Who Lee, Wooseong Choi, Bongkun Chang, Eun-Ju
Published in
BMB Reports
Endothelial dysfunction-induced lipid retention is an early feature of atherosclerotic lesion formation. Apoptosis of vascular smooth muscle cells (VSMCs) is one of the major modulating factors of atherogenesis, which accelerates atherosclerosis progression by causing plaque destabilization and rupture. However, the mechanism underlying VSMC apopto...
