Nakai, Tomoko Sakai, Daisuke Nakamura, Yoshihiko Horikita, Natsumi Matsushita, Erika Naiki, Mitsuru Watanabe, Masahiko
Published in
BMC Medical Genomics
BackgroundIntervertebral disc degeneration, one of the major causes of low-back pain, results from altered biosynthesis/turnover of extracellular matrix in the disc. Previously, we reported that the analgesic drug Neurotropin® (NTP) had an anabolic effect on glycosaminoglycan synthesis in cultured nucleus pulposus (NP) cells via the stimulation of ...
Faienza, Maria Felicia Chiarito, Mariangela Brunetti, Giacomina D'Amato, Gabriele
Published in
Endocrine
Short stature is a common clinical presentation, thus it is widely accepted that it is a polygenic trait. However, genome wide association and next generation sequencing studies have recently challenged this view, suggesting that many of the children classified as idiopathic short stature could instead have monogenic defects. Linear growth is deter...
Neuman, Paul Larsson, Staffan Lohmander, L. Stefan Struglics, André
Published in
BMC Musculoskeletal Disorders
BackgroundTo investigate if cartilage related biomarkers in synovial fluid are associated with knee cartilage status 20 years after an anterior cruciate ligament (ACL) injury.MethodsWe studied 25 patients with a complete ACL rupture without subsequent ACL reconstruction or radiographic knee OA. All had a delayed gadolinium-enhanced magnetic resonan...
Kim, Tae Youp Jang, Kyung Mi Keum, Chang Won Oh, Seung Hwan Chung, Woo Yeong
Published in
Annals of Pediatric Endocrinology & Metabolism
Longitudinal bone growth is primarily mediated by the growth plate, which is a specialized cartilaginous structure. Aggrecan, encoded by ACAN , is a primary proteoglycan component of the extracellular matrix in both the growth plate and articular cartilage. Aggrecanopathies have emerged as a phenotype of genetic skeletal disease in humans. A hetero...
Wang, Chao Brisson, Becky K Terajima, Masahiko Li, Qing Hoxha, Kevt'her Han, Biao Goldberg, Abby M Sherry Liu, X Marcolongo, Michele S Enomoto-Iwamoto, Motomi
...
Published in
Matrix biology : journal of the International Society for Matrix Biology
Despite the fact that type III collagen is the second most abundant collagen type in the body, its contribution to the physiologic maintenance and repair of skeletal tissues remains poorly understood. This study queried the role of type III collagen in the structure and biomechanical functions of two structurally distinctive tissues in the knee joi...
Liu, Fuen Li, Lei Lu, Wei Ding, Zhenfei Huang, Wei Li, Ye Tian Cheng, Chao Shan, Wen Shan Xu, Jiegou He, Wei
...
Published in
International immunopharmacology
Osteoarthritis (OA) is a chronic inflammatory disease that is the basis of cartilage extracellular matrix degeneration and joint inflammation. Scutellarin is an herbal flavonoid glucuronide, isolated from the Chinese traditional herb Erigeron breviscapus, has been reported to have anti-inflammatory effect. Here, we showed that Scutellarin could inh...
Rosadi, Imam Karina, Karina Rosliana, Iis Sobariah, Siti Afini, Irsyah Widyastuti, Tias Barlian, Anggraini
Published in
Stem Cell Research & Therapy
BackgroundCartilage tissue engineering is a promising technique for repairing cartilage defect. Due to the limitation of cell number and proliferation, mesenchymal stem cells (MSCs) have been developed as a substitute to chondrocytes as a cartilage cell-source. This study aimed to develop cartilage tissue from human adipose-derived stem cells (ADSC...
Shi, Jinhui Zhou, Xichao Wang, Zhen Kurra, Swamy Niu, Junjie Yang, Huilin
Published in
BMC Musculoskeletal Disorders
BackgroundDegenerative intervertebral disc (IVD) disease can cause lower back pain. However, the change of lactic acid content during disc degeneration process still unclear. The objective of this study was to investigate whether the change of the content of lactic acid is associated with depletion of degenerative intervertebral disc extracellular ...
Szegeczki, Vince Bauer, Balázs Jüngling, Adél Fülöp, Balázs Daniel Vágó, Judit Perényi, Helga Tarantini, Stefano Tamás, Andrea Zákány, Róza Reglődi, Dóra
...
Published in
GeroScience
Pituitary adenylate cyclase activating polypeptide (PACAP) is an evolutionarly conserved neuropeptide which is produced by various neuronal and non-neuronal cells, including cartilage and bone cells. PACAP has trophic functions in tissue development, and it also plays a role in cellular and tissue aging. PACAP takes part in the regulation of chondr...
Novais, Emanuel J Diekman, Brian O Shapiro, Irving M Risbud, Makarand V
Published in
Matrix biology : journal of the International Society for Matrix Biology
Intervertebral disc degeneration is an important contributor to chronic low back and neck pain. Although many environmental and genetic factors are known to contribute to disc degeneration, age is still the most significant risk factor. Recent studies have shown that senescence may play a role in age-related disc degeneration and matrix catabolism ...
