da Fonseca, Aluísio Marques Luthierre Gama Cavalcante, Antônio Mendes, Antônia Mayara Dos Santos da Silva, Francisco Danilo Ferreira Cost... Ferreira, Débora Cristina Lima Ribeiro, Paulo Riceli Vasconcelos Dos Santos, José Cleiton Sousa Dos Santos, Hélcio Silva Gaieta, Eduardo Menezes Marinho, Gabrielle Silva
...
Published in
Journal of biomolecular structure & dynamics
Lantana camara L. (Verbenaceae), commonly called lead cambará, has often been used in folk medicine as antiseptic, antispasmodic, against hemorrhages, flu, colds, and diarrheic. This plant is considered a weed and an ornamental and medicinal plant and is an essential source of natural organic compounds, mainly flavonoids. This work aims to investig...
Lolak, Nebih Akocak, Süleyman Durgun, Mustafa Duran, Hatice Esra Necip, Adem Türkeş, Cüneyt Işık, Mesut Beydemir, Şükrü
Published in
Molecular diversity
To discover alternative substances to compounds used to treat many diseases, especially treating Alzheimer's disease (AD) and Parkinson's disease targeting carbonic anhydrase (hCA) and acetylcholinesterase (AChE) enzymes, is important. For this purpose, a series of novel bis-ureido-substituted sulfaguanidine (SG1-4) and sulfisoxazole (SO1-4) deriva...
Martins, Illana Kemmerich; Pereira, Leonardo Gomes; Nunes, Mauro Eugenio Medina; Lopes, Andressa Rubim; Leandro, Luana Paganotto; de Mello, Renata Siqueira; Mariano, Maria Vitoria Takemura; Franco, Jeferson Luis; Posser, Thais;
Mancozeb is a widely used fungicide whose toxicity has been reported in non-target organisms, being considered to have high or very high acute toxicity to aquatic organisms. However, the toxicity of this compound is not well characterized in the developmental stages of fish. In this study, Danio rerio with 4-, 5-, and 6-days post fertilization (dpf...
Aljubiri, Salha M. Elsalam, Eman Abd Abd El Hady, Faten K. Radwan, Mohamed O. Almansour, Abdulrahman I. Shaker, Kamel H.
Published in
Zeitschrift für Naturforschung C
Acetylcholinesterase, tyrosinase, and α-glucosidase inhibition activities of Euphorbia schimperiana and Euphorbia balsamifera extracts, fractions, and available pure compounds were evaluated for the first time. Acetylcholinesterase assay revealed a significant inhibitory activity of E. balsamifera total extract and n-hexane fraction with 47.7% and ...
Abedini, Fatemeh Amjadi, Omolbanin Hedayatizadeh-Omran, Akbar Lira, Sergio A Ahangari, Ghasem
Published in
Oncology
Introduction: Gastric cancer is one of the common causes of cancer-related death in the world. Neurotransmitters have recently been related to the proliferation of cancer cells, but the role of neurotransmitters in the progression of gastric cancer is still unexplored. The cross-talk between the nervous system and immune cells through serotonin and...
Kukavica, Biljana Davidović-Plavšić, Biljana Savić, Ana Dmitrović, Dejan Šukalo, Goran Đurić-Savić, Sandra Vučić, Goran
Published in
Biological trace element research
Despite not being redox-active metals, Cd and Zn can disrupt cellular redox homeostasis by acting pro-oxidatively. The aim of this study was to examine the effects of exposure to Zn (14 and 72 mg/L) and Cd (7.7 and 77 mg/L) for 24 and 48 h on oxidative and antioxidative parameters and the activity of glutathione-S-transferase in Artemia franciscana...
Niquet, Jerome Nguyen, Donna Furtado, Marcio Araujo Lumley, Lucille
Despite new antiseizure medications, the development of cholinergic-induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly develops. Studies conducted by Epilepsia. 2005;46:142 demonstrated that the initiation and maintenance of cholinerg...
Mateev, Emilio Kondeva-Burdina, Magdalena Georgieva, Maya Zlatkov, Alexander
Published in
Journal of molecular graphics & modelling
An in silico consensus molecular docking approach and in vitro evaluations were adopted in the present study to explore a dataset of FDA-approved drugs as novel multitarget MAO-B/AChE agents in the treatment of Alzheimer's disease (AD). GOLD 5.3 and Glide were employed in the virtual assessments and consensus superimpositions of the obtained poses ...
Taha, Muhammad Rahim, Fazal Zaman, Khalid Anouar, El Hassane Uddin, Nizam Nawaz, Faisal Sajid, Muhammad Khan, Khalid Mohammed Shah, Adnan Ali Wadood, Abdul
...
Published in
Journal of biomolecular structure & dynamics
We have synthesized benzo[d]oxazole derivatives (1-21) through a multistep reaction. Alteration in the structure of derivatives was brought in the last step via using various substituted aromatic aldehydes. In search of an anti-Alzheimer agent, all derivatives were evaluated against acetylcholinesterase and butyrylcholinesterase enzyme under positi...
Saleem, Uzma Chauhdary, Zunera Islam, Sumera Zafar, Aimen Khayat, Rana O Althobaiti, Norah A Shah, Ghulam Mujtaba Alqarni, Mohammed Shah, Muhammad Ajmal
Published in
Metabolic brain disease
Sarcococca saligna is a valuable source of bioactive secondary metabolites exhibiting antioxidant, anti-inflammatory and acetylcholinesterase inhibitory activities. The study was intended to explore the therapeutic pursuits of S. saligna in amelioration of cognitive and motor dysfunctions induced by D-galactose and linked mechanistic pathways. Alzh...
