Following our study of 4'-truncated (N)-methanocarba-adenosine derivatives that displayed unusually high mouse (m) A3AR affinity, we incorporated dopamine-related N6 substituents in the full agonist 5'-methylamide series. N6-(2-(4-Hydroxy-3-methoxy-phenyl)ethyl) derivative MRS7618 11 displayed Ki (nM) 0.563 at hA3AR (∼20,000-fold selective) and 1.5...
Torfs, ElenaNicolai, NielsDaneshgar, SabaCopp, John B.Haimi, HenriIkumi, DavidJohnson, BrucePlosz, Benedek B.Snowling, SpencerTownley, Lloyd R.
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Digital Twins (DTs) are on the rise as innovative, powerful technologies to harness the power of digitalisation in the WRRF sector. The lack of consensus and understanding when it comes to the definition, perceived benefits and technological needs of DTs is hampering their widespread development and application. Transitioning from traditional WRRF ...
Manzini, NicolasMar, NdeyeSchmidt, FranziskaBercher, Jean-FrançoisOrcesi, AndréMarchand, PierreGazeaux, JulienThom, Christian
Eurostruct 2021, Proceedings of the 1st Conference of the European Association on Quality Control of Bridges and Structures, Padoue, ITALIE, 29-/08/2021 - 01/09/2021
Making the transition to long-term interaction with social-robot systems has been identified as one of the main challenges in human-robot interaction. This article identifies four design principles to address this challenge and applies them in a real-world implementation: cloud-based robot control, a modular design, one common knowledge base for al...
Active visual scanning of the scene is a key task-element in all forms of human locomotion. In the field of driving, steering (lateral control) and speed adjustments (longitudinal control) models are largely based on drivers' visual inputs. Despite knowledge gained on gaze behaviour behind the wheel, our understanding of the sequential aspects of t...
Harb, MustaphaMalik, JaiCircella, GiovanniWalker, Joan
To explore potential travel behavior shifts induced by personally owned, fully autonomous vehicles (AVs), we ran an experiment that provided personal chauffeurs to 43 households in the Sacramento region to simulate life with an AV. Like an advanced AV, the chauffeurs took over driving duties. Households were recruited from the 2018 Sacramento house...
