Patil, Pratik Rajendra Vithani, Neha Singh, Virender Kumar, Ashok Prakash, Balaji
Published in
The Journal of Biological Chemistry
Bacterial Rel proteins synthesize hyperphosphorylated guanosine nucleotides, denoted as (p)ppGpp, which by inhibiting energy requiring molecular pathways help bacteria to overcome the depletion of nutrients in its surroundings. (p)ppGpp synthesis by Rel involves transferring a pyrophosphate from ATP to the oxygen of 3′-OH of GTP/GDP. Initially, a c...
Bragança, Bruno Correia-de-Sá, Paulo
Published in
International Journal of Molecular Sciences
Adenosine triphosphate (ATP) is a primordial versatile autacoid that changes its role from an intracellular energy saver to a signaling molecule once released to the extracellular milieu. Extracellular ATP and its adenosine metabolite are the main activators of the P2 and P1 purinoceptor families, respectively. Mounting evidence suggests that the i...
Wirsching, Eva Fauler, Michael Fois, Giorgio Frick, Manfred
Published in
International Journal of Molecular Sciences
The distal lung provides an intricate structure for gas exchange in mammalian lungs. Efficient gas exchange depends on the functional integrity of lung alveoli. The cells in the alveolar tissue serve various functions to maintain alveolar structure, integrity and homeostasis. Alveolar epithelial cells secrete pulmonary surfactant, regulate the alve...
Gomez-Villafuertes, Rosa Adinolfi, Elena
Published in
Frontiers in Pharmacology
Campos-Contreras, Anaí del Rocío Díaz-Muñoz, Mauricio Vázquez-Cuevas, Francisco G.
Published in
Cells
Cancer is a complex expression of an altered state of cellular differentiation associated with severe clinical repercussions. The effort to characterize this pathological entity to understand its underlying mechanisms and visualize potential therapeutic strategies has been constant. In this context, some cellular (enhanced duplication, immunologica...
Reichert, Karine P Pillat, Micheli M Schetinger, Maria Rosa C Bottari, Nathieli B Palma, Tais V Assmann, Charles E Gutierres, Jessie M Ulrich, Henning Andrade, Cinthia M Exley, Christopher
...
Published in
Chemosphere
The ubiquitous presence of aluminum in the environment leads to a high likelihood of human exposure. Neurotoxicity of the trivalent cationic form of this metal (Al3+) occurs in the central nervous system via accumulation of Al in cells of neural origin, including neural progenitor cells (NPCs). NPCs play a key role in the development and regenerati...
Jin, Zhuping Zhang, Quanxi Wondimu, Eden Verma, Richa Fu, Ming Shuang, Tian Arif, Hassan Mustafa Wu, Lingyun Wang, Rui
Published in
American journal of physiology. Regulatory, integrative and comparative physiology
The production of H2S and its effect on bioenergetics in mammalian cells may be evolutionarily preserved. Erythrocytes of birds, but not those of mammals, have a nucleus and mitochondria. In the present study, we report the endogenous production of H2S in chicken erythrocytes, which was mainly catalyzed by 3-mercaptopyruvate sulfur transferase (MST...
Vahabi, Bahareh Jabr, Rita Fry, Chris McCloskey, Karen Everaert, Karel Agudelo, Christina W Monaghan, Thomas F Rahnama'i, Mohammad S Panicker, Jalesh N Weiss, Jeffrey P
...
Published in
Neurourology and urodynamics
The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urothelium in the pathophysiology of nocturia; (b) to determine whether nocturia is a circadian disorder; (c) to discuss the role ...
Kuang, Yuanyuan Zorzi, Veronica Buratto, Damiano Ziraldo, Gaia Mazzarda, Flavia Peres, Chiara Nardin, Chiara Salvatore, Anna Maria Chiani, Francesco Scavizzi, Ferdinando
...
Published in
EBioMedicine
Numerous currently incurable human diseases have been causally linked to mutations in connexin (Cx) genes. In several instances, pathological mutations generate abnormally active Cx hemichannels, referred to also as "leaky" hemichannels. The goal of this study was to assay the in vivo efficacy of a potent antagonist antibody targeting Cx hemichanne...
Tseng, Chun-Chieh Lu, Yi-Chian Chang, Kai-Chih Hung, Chien-Che
Published in
Microorganisms
Rapid monitoring of the microbial content in indoor air is an important issue. In this study, we develop a method for applying a Coriolis sampler coupled with a portable ATP luminometer for characterization of the collection efficiency of bioaerosol samplers and then test this approach in field applications. The biological collection efficiencies o...
