Liu, Shanshan Zheng, Sitian Chu, Jing
Published in
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
In this work, a novel colorimetric assay based on polythiophene derivative (PMNT) was designed for the detection of protein kinase A (PKA). PKA can catalyze the phosphorylation of peptide, leading to the conformation change of PMNT from random-coil to planar, with the disappearance of absorption peaks above 500 nm and a color change from pink to ye...
García-Carlos, Carlos Antonio Camargo-Loaiza, Julio Andrés García-Villa, Denisse López-Cervantes, José Guillermo Domínguez-Avila, J Abraham González-Aguilar, Gustavo A Astiazaran-Garcia, Humberto Montiel-Herrera, Marcelino
Published in
Cell biochemistry and function
The meninges shield the nervous system from diverse, rather harmful stimuli and pathogens from the periphery. This tissue is composed of brain endothelial cells (BECs) that express diverse ion channels and chemical-transmitter receptors also expressed by neurons and glial cells to communicate with each other. However, information about the effects ...
Wiprich, Melissa Talita Bonan, Carla Denise
Published in
Frontiers in Neuroscience
Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia, and motor incoordination in the late stage), psychiatric disturbance, and cognitive decline. The...
Nukui, Takamasa Matsui, Atsushi Niimi, Hideki Sugimoto, Tomoyuki Hayashi, Tomohiro Dougu, Nobuhiro Konishi, Hirofumi Yamamoto, Mamoru Anada, Ryoko Matsuda, Noriyuki
...
Published in
BMC Neurology
BackgroundExtracellular adenosine 5'-triphosphate (ATP) has been suggested to cause neuroinflammation and motor neuron degeneration by activating microglia and astrocytes in amyotrophic lateral sclerosis (ALS). Since we have developed a highly sensitive ATP assay system, we examined cerebrospinal fluid (CSF) ATP levels in patients with ALS whether ...
Mai, Yonglin Guo, Zhihua Yin, Weiqiang Zhong, Nanshan Dicpinigaitis, Peter V. Chen, Ruchong
Published in
Frontiers in Oncology
Symptoms associated with lung cancer mainly consist of cancer-associated pain, cough, fatigue, and dyspnea. However, underlying mechanisms of lung cancer symptom clusters remain unclear. There remains a paucity of effective treatment to ameliorate debilitating symptoms and improve the quality of life of lung cancer survivors. Recently, extracellula...
Chu, Binbin Wang, Ajun Cheng, Liang Chen, Runzhi Shi, Huayi Song, Bin Dong, Fenglin Wang, Houyu He, Yao
Published in
Journal of Nanobiotechnology
BackgroundEx vivo and in vivo detection and imaging of adenosine triphosphate (ATP) is critically important for the diagnosis and treatment of diseases, which still remains challenges up to present.ResultsWe herein demonstrate that ATP could be fluorescently detected and imaged ex vivo and in vivo. In particular, we fabricate a kind of fluorescent ...
Sarojini, Harshini Bajorek, Alexander Wan, Rong Wang, Jianpu Zhang, Qunwei Billeter, Adrian T. Chien, Sufan
Published in
Frontiers in Pharmacology
This study sought to use a newly developed intracellular ATP delivery to enhance incisional wound healing to reduce surgical wound dehiscence and to explore possible mechanism for this effect. Thirty-five adult New Zealand white rabbits were used. Skin incisions were made on the back and closed. ATP-vesicles were mixed with a neutral cream for one ...
Ye, Shan-Shan Tang, Yong Song, Jian-Tao
Published in
Frontiers in Pharmacology
Extracellular ATP and its ultimate degradation product adenosine are potent extracellular signaling molecules that elicit a variety of pathophysiological pathways in retina through the activation of P2 and P1 purinoceptors, respectively. Excessive build-up of extracellular ATP accelerates pathologic responses in retinal diseases, whereas accumulati...
Wei, Xu Mira, Amany Yu, Qibin Gmitter, Fred G. Jr.
Published in
Frontiers in Plant Science
Citrus Huanglongbing (HLB) is the most devastating disease of citrus, presumably caused by “Candidatus Liberibacter asiaticus” (CaLas). Although transcriptomic profiling of HLB-affected citrus plants has been studied extensively, the initial steps in pathogenesis have not been fully understood. In this study, RNA sequencing (RNA-seq) was used to co...
Rizzardi, Nicola Liparulo, Irene Antonelli, Giorgia Orsini, Francesca Riva, Antonella Bergamini, Christian Fato, Romana
Published in
Antioxidants (Basel, Switzerland)
Coenzyme Q10 (CoQ10) is a lipid-soluble molecule with a dual role: it transfers electrons in the mitochondrial transport chain by promoting the transmembrane potential exploited by the ATPase to synthesize ATP and, in its reduced form, is a membrane antioxidant. Since the high CoQ10 hydrophobicity hinders its bioavailability, several formulations h...
