ENDOCRINE STUDIES OF A NONSTEROID ANTI-ANDROGEN AND PROGESTIN.
Published in Endocrinology
Published in Endocrinology
Published in The Biochemical journal
1. The inhibition of NAD-linked 3alpha-hydroxy steroid dehydrogenase in vitro by some of the more therapeutically effective antimetabolic drugs has been investigated. 2. Antipurine and antifolic acid drugs inhibit this system, as does folic acid. 3. Combinations of antifolic acid drugs and folic acid itself produce an additive but not synergic inhi...
Published in The Biochemical journal
1. Nicotinamide nucleotide-linked mitochondrial oxidations were inhibited by the disulphides NNN'N'-tetraethylcystamine, cystamine and cystine diethyl ester, whereas l-homocystine, oxidized mercaptoethanol, oxidized glutathione, NN'-diacetylcystamine and tetrathionate were only slightly inhibitory. Mitochondrial oxidations were not blocked by the t...
Published in Experimental parasitology
Published in Radiation research
Published in The Biochemical journal
1. Rat-liver mitochondria showed a decrease in amino acid production after preparation in 0.25m-sucrose containing EDTA (1mm), but an increase in water content. When EDTA was replaced by Mn(2+) (1mm) or succinate (1mm), both amino acid production and water content were lowered, whereas preparation in 0.9% potassium chloride caused an increase in bo...
Published in The Journal of experimental medicine
The effect of DNA antagonists and various antibiotics on steps in the synthesis of SV40 virus in green monkey kidney cells was investigated. Both the early forming tumor (T) antigen, as well as the later synthesized virus (V) antigen, were synthesized in the presence of fluorouracil and iododeoxyuridine. Cytosine arabinoside (and fluorodeoxyuridine...
Published in Biochimica et biophysica acta
Published in The Medical journal of Australia
Published in Journal of the American Chemical Society