Genetic ancestry has the same major problems as phenotypic ancestry
Epstein-Barr virus genome deletions in Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases
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The main target cells for Epstein-Barr virus (EBV) infection and persistence are B lymphocytes, although T and NK cells can also become infected. In this paper we characterise the EBV present in 21 pediatric and adult patients treated in France for a range of diseases that involve infection of T or NK cells. Of these 21 cases, 5 pediatric patients ...
Vertical sleeve gastrectomy lowers SGLT2/Slc5a2 expression in the mouse kidney
Bariatric surgery improves glucose homeostasis but the underlying mechanisms are not fully elucidated. Here, we show that the expression of sodium glucose cotransporter-2 (SGLT2/Slc5a2) is reduced in the kidney of lean and obese mice following vertical sleeve gastrectomy (VSG). Indicating an important contribution of altered cotransporter expressio...
Recommended reading from the Imperial College, London fellows
Supplementary oxygen is widely used in critically unwell patients; however, the optimal regime of oxygen therapy is a topic of ongoing debate. Although hypoxemia is dangerous, in vitro evidence suggests that exposing alveolar epithelium to supranormal oxygen concentration causes free radical formation (1). Clinically, hyperoxia (defined as a PaO2 v...
Therapeutic Targeting of the Respiratory Microbiome.
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The last decade of research has revolutionized our understanding of respiratory microbiology, revealing that the lungs and airways contain diverse and dynamic microbial communities in health and disease. This "respiratory ecosystem"-a densely interconnected environment of microbial and host interactions-represents a tremendous and under-appreciated...
Community-based interventions for improving mental health in refugee children and adolescents in high-income countries
Background An unprecedented number of people around the world are experiencing forced displacement due to natural or man‐made events. More than 50% of refugees worldwide are children or adolescents. In addition to the challenges of settling in a new country, many have witnessed or experienced traumatic events. Therefore, refugee children and adoles...
Investigating the pro-fibrotic effects of galectins in idiopathic pulmonary fibrosis - a potential role for glycan-media...
Evaluation of the Growth Assessment Protocol (GAP) for antenatal detection of small for gestational age: The DESiGN clus...
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BACKGROUND: Antenatal detection and management of small for gestational age (SGA) is a strategy to reduce stillbirth. Large observational studies provide conflicting results on the effect of the Growth Assessment Protocol (GAP) in relation to detection of SGA and reduction of stillbirth; to the best of our knowledge, there are no reported randomise...
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning
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Precise vascular patterning is critical for normal growth and development. The ERG transcription factor drives Delta like ligand 4 (DLL4)/Notch signalling and is thought to act as pivotal regulators of endothelial cell (EC) dynamics and developmental angiogenesis. However, molecular regulation of ERG activity remains obscure. Using a series of EC s...
DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy dependent mechanism
The changes that drive differentiation facilitate the emergence of abnormal cells that need to be removed before they contribute to further development or the germline. Consequently, in mice in the lead-up to gastrulation, ∼35% of embryonic cells are eliminated. This elimination is caused by hypersensitivity to apoptosis, but how it is regulated is...
