SCHRAMM, Antoine Lieutaud, Philippe Gianni, Stefano Longhi, Sonia Bignon, Christophe
InSiDDe (In Silico Disorder Design) is a program for the in silico design of intrinsically disordered proteins of desired length and disorder probability. The latter is assessed using IUPred and spans values ranging from 0.55 to 0.95 with 0.05 increments. One to ten artificial sequences per query, each made of 50 to 200 residues, can be generated b...
Delgado, Félix Torres, Karina Castellanos, Jaime Romero-Sánchez, Consuelo Simon-Loriere, Etienne Sakuntabhai, Anavaj Roth, Claude
The high levels of dengue-virus (DENV) seroprevalence in areas where the Zika virus (ZIKV) is circulating and the cross-reactivity between these two viruses have raised concerns on the risk of increased ZIKV disease severity for patients with a history of previous DENV infections. To determine the role of DENV preimmunity in ZIKV infection, we anal...
Delgado, Félix Torres, Karina Castellanos, Jaime Romero-Sánchez, Consuelo Simon-Loriere, Etienne Sakuntabhai, Anavaj Roth, Claude
The high levels of dengue-virus (DENV) seroprevalence in areas where the Zika virus (ZIKV) is circulating and the cross-reactivity between these two viruses have raised concerns on the risk of increased ZIKV disease severity for patients with a history of previous DENV infections. To determine the role of DENV preimmunity in ZIKV infection, we anal...
Charon, Justine Barra, Amandine Walter, Jocelyne Millot, Pauline Hébrard, Eugénie Moury, Benoît Michon, Thierry
Published in
Molecular biology and evolution
Intrinsic disorder (ID) in proteins is defined as a lack of stable structure in physiological conditions. Intrinsically disordered regions (IDRs) are highly abundant in some RNA virus proteomes. Low topological constraints exerted on IDRs are expected to buffer the effect of numerous deleterious mutations and could be related to the remarkable adap...
SCHRAMM, Antoine Lieutaud, Philippe Gianni, Stefano Longhi, Sonia Bignon, Christophe
InSiDDe (In Silico Disorder Design) is a program for the in silico design of intrinsically disordered proteins of desired length and disorder probability. The latter is assessed using IUPred and spans values ranging from 0.55 to 0.95 with 0.05 increments. One to ten artificial sequences per query, each made of 50 to 200 residues, can be generated b...
Vallbracht, Melina Brun, Delphine Tassinari, Matteo Vaney, Marie-Christine Pehau-Arnaudet, Gérard Guardado-Calvo, Pablo Haouz, Ahmed Klupp, Barbara G Mettenleiter, Thomas C Rey, Felix A
...
Published in
Journal of virology
Conserved across the family Herpesviridae, glycoprotein B (gB) is responsible for driving fusion of the viral envelope with the host cell membrane for entry upon receptor binding and activation by the viral gH/gL complex. Although crystal structures of the gB ectodomains of several herpesviruses have been reported, the membrane fusion mechanism has...
SCHRAMM, Antoine Lieutaud, Philippe Gianni, Stefano Longhi, Sonia Bignon, Christophe
InSiDDe (In Silico Disorder Design) is a program for the in silico design of intrinsically disordered proteins of desired length and disorder probability. The latter is assessed using IUPred and spans values ranging from 0.55 to 0.95 with 0.05 increments. One to ten artificial sequences per query, each made of 50 to 200 residues, can be generated b...
Sulzenbacher, Gerlind Roig-Zamboni, Véronique Lebrun, Régine Guérardel, Yann Murat, Dorothée Mansuelle, Pascal Yamakawa, Nao Qian, Xin-Xin Vincentelli, Renaud Bourne, Yves
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Published in
Environmental microbiology
The flagella of various Gram-negative bacteria are decorated with diverse glycan structures, amongst them nonulosonic acids related to the sialic acid family. Although nonulosonic sugar biosynthesis pathways have been dissected in various pathogens, the enzymes transferring the sugars onto flagellin are still poorly characterized. The deletion of g...
Delgado, Félix Torres, Karina Castellanos, Jaime Romero-Sánchez, Consuelo Simon-Loriere, Etienne Sakuntabhai, Anavaj Roth, Claude
The high levels of dengue-virus (DENV) seroprevalence in areas where the Zika virus (ZIKV) is circulating and the cross-reactivity between these two viruses have raised concerns on the risk of increased ZIKV disease severity for patients with a history of previous DENV infections. To determine the role of DENV preimmunity in ZIKV infection, we anal...
SCHRAMM, Antoine Lieutaud, Philippe Gianni, Stefano Longhi, Sonia Bignon, Christophe
InSiDDe (In Silico Disorder Design) is a program for the in silico design of intrinsically disordered proteins of desired length and disorder probability. The latter is assessed using IUPred and spans values ranging from 0.55 to 0.95 with 0.05 increments. One to ten artificial sequences per query, each made of 50 to 200 residues, can be generated b...