David, Maude M. Tataru, Christine Daniels, Jena Schwartz, Jessey Keating, Jessica Hampton-Marcell, Jarrad Gottel, Neil Gilbert, Jack A. Wall, Dennis P.
Published in
mSystems
The existence of a link between the gut microbiome and autism spectrum disorder (ASD) is well established in mice, but in human populations, efforts to identify microbial biomarkers have been limited due to a lack of appropriately matched controls, stratification of participants within the autism spectrum, and sample size. To overcome these limitat...
Cross, Karissa L. Leigh, Brittany A. Hatmaker, E. Anne Mikaelyan, Aram Miller, Asia K. Bordenstein, Seth R.
Published in
mSystems
Phylosymbiosis is a cross-system trend whereby microbial community relationships recapitulate the host phylogeny. In Nasonia parasitoid wasps, phylosymbiosis occurs throughout development, is distinguishable between sexes, and benefits host development and survival. Moreover, the microbiome shifts in hybrids as a rare Proteus bacterium in the micro...
Bennett, Gordon M. Heath-Heckman, Elizabeth Sogin, E. Maggie
Published in
mSystems
Symbioses between hosts and beneficial microbes are key drivers of biological innovation and diversity. While a range of systems have emerged that provide foundational insights into how symbioses function and evolve, we still have a limited understanding of the vast diversity of organisms that engage in such interactions. Recent advances in molecul...
Sun, Xiao Cui, Yalei Su, Yingying Gao, Zimin Diao, Xinying Li, Ju Zhu, Xiaoyan Li, Defeng Li, Zhentian Wang, Chengzhang
...
Published in
mSystems
Weaning of piglets is accompanied by intestinal inflammation, impaired intestinal barrier function, and intestinal microflora disorder. Regulating intestinal microflora structure can directly or indirectly affect intestinal health and host growth and development. However, whether dietary fiber (DF) affects the inflammatory response and barrier func...
Cooper, Reilly O. Vavra, Janna M. Cressler, Clayton E.
Published in
mSystems
Host-associated microbes contribute to host fitness, but it is unclear whether these contributions are from rare keystone taxa, numerically abundant taxa, or interactions among community members. Experimental perturbation of the microbiota can highlight functionally important taxa; however, this approach is primarily applied in systems with complex...
Wani, Sajad Ahmad Praharaj, Manas Ranjan Sahu, Amit R Khan, Raja Ishaq Nabi Saxena, Shikha Rajak, Kaushal Kishor Muthuchelvan, Dhanavelu Sahoo, Aditya Mishra, Bina Singh, Raj Kumar
...
Published in
mSystems
Immune response is a highly coordinated cascade involving all the subsets of peripheral blood mononuclear cells (PBMCs). In this study, RNA sequencing (RNA-Seq) analysis of PBMC subsets was done to delineate the systems biology behind immune protection of the vaccine in sheep and goats. The PBMC subsets studied were CD4+, CD8+, CD14+, CD21+, and CD...
Lampe, Robert H Hernandez, Gustavo Lin, Yuan Yu Marchetti, Adrian
Published in
mSystems
Wind-driven upwelling followed by relaxation results in cycles of cold nutrient-rich water fueling intense phytoplankton blooms followed by nutrient depletion, bloom decline, and sinking of cells. Surviving cells at depth can then be vertically transported back to the surface with upwelled waters to seed another bloom. As a result of these cycles, ...
Iyer, Mahesh S Pal, Ankita Srinivasan, Sumana Somvanshi, Pramod R Venkatesh, K V
Published in
mSystems
Global transcriptional regulators coordinate complex genetic interactions that bestow better adaptability for an organism against external and internal perturbations. These transcriptional regulators are known to control an enormous array of genes with diverse functionalities. However, regulator-driven molecular mechanisms that underpin precisely t...
Wan, Wenjie Liu, Song Li, Xiang Xing, Yonghui Chen, Wenli Huang, Qiaoyun
Published in
mSystems
Bacterial diversity and ecosystem multifunctionality (EMF) vary along environmental gradients. However, little is known about interconnections between EMF and taxonomic and phylogenetic diversities of rare and abundant bacteria. Using MiSeq sequencing and multiple statistical analyses, we evaluated the maintenance of taxonomic and phylogenetic dive...
Ruiz-Perez, Daniel Lugo-Martinez, Jose Bourguignon, Natalia Mathee, Kalai Lerner, Betiana Bar-Joseph, Ziv Narasimhan, Giri
Published in
mSystems
A key challenge in the analysis of longitudinal microbiome data is the inference of temporal interactions between microbial taxa, their genes, the metabolites that they consume and produce, and host genes. To address these challenges, we developed a computational pipeline, a pipeline for the analysis of longitudinal multi-omics data (PALM), that fi...
