Li, Jiang Yu, Yuefeng Sun, Ying Fu, Yanqi Shen, Wenqi Cai, Lingli Tan, Xiao Cai, Yan Wang, Ningjian Lu, Yingli
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Published in
eLife
Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in predicting the progression from prediabetes to diabetes. This prospective study included 13,489 participants with prediabetes w...
Jana, Samarjit Mondal, Mainak Mahale, Sagar Gupta, Bhavana Prasasvi, Kaval Reddy Kandasami, Lekha Jha, Neha Chowdhury, Abhishek Santosh, Vani Kanduri, Chandrasekhar
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Published in
eLife
In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, PITAR (p53 Inactivating TRIM28 Associated RNA), as an inhibitor of p53. PITAR is an oncogenic Cancer/testis lncRNA and is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We establish that TRIM28 mRNA,...
Barr, Jeffrey Walz, Austin Restaino, Anthony C Amit, Moran Barclay, Sarah M Vichaya, Elisabeth G Spanos, William C Dantzer, Robert Talbot, Sebastien Vermeer, Paola D
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Published in
eLife
A lot of cancer survivors experience a decline in mental health, persisting often decades after successful treatment. Many factors contribute to this reduced mental well-being, including the physical, emotional and financial stresses they experience. Scientists think that the increased prevalence of mental health disorders among cancer patients and...
Ehring, Kristina Ehlers, Sophia Friederike Froese, Jurij Gude, Fabian Puschmann, Janna Grobe, Kay
Published in
eLife
The Sonic hedgehog (Shh) signaling pathway controls embryonic development and tissue homeostasis after birth. This requires regulated solubilization of dual-lipidated, firmly plasma membrane-associated Shh precursors from producing cells. Although it is firmly established that the resistance-nodulation-division transporter Dispatched (Disp) drives ...
Biswas, Parijat Roy, Priyanka Jana, Subhamoy Ray, Dipanjan Das, Jibitesh Chaudhuri, Bipasa Basunia, Ridita Ray Sinha, Bidisha Sinha, Deepak Kumar
Published in
eLife
The excessive cosolute densities in the intracellular fluid create a physicochemical condition called macromolecular crowding (MMC). Intracellular MMC entropically maintains the biochemical thermodynamic equilibria by favouring associative reactions while hindering transport processes. Rapid cell volume shrinkage during extracellular hypertonicity ...
Wiriyasermkul, Pattama Moriyama, Satomi Suzuki, Masataka Kongpracha, Pornparn Nakamae, Nodoka Takeshita, Saki Tanaka, Yoko Matsuda, Akina Miyasaka, Masaki Hamase, Kenji
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Published in
eLife
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal physiological functions of the transporters. While d-serine, a trace enantiomer of serine in the circulation, was...
Varadharajan, Venkateshwari Ramachandiran, Iyappan Massey, William J Jain, Raghav Banerjee, Rakhee Horak, Anthony J McMullen, Megan R Huang, Emily Bellar, Annette Lorkowski, Shuhui W
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Published in
eLife
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced MBOAT7 expression is implicated in non-alcoholic fatty liver disease (NAFLD), alcohol-associated liver diseas...
Zhu, Bohan Ainsworth, Richard I Wang, Zengmiao Liu, Zhengzhi Sierra, Salvador Deng, Chengyu Callado, Luis F Meana, J Javier Wang, Wei Lu, Chang
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Published in
eLife
Genome-wide association studies have revealed >270 loci associated with schizophrenia risk, yet these genetic factors do not seem to be sufficient to fully explain the molecular determinants behind this psychiatric condition. Epigenetic marks such as post-translational histone modifications remain largely plastic during development and adulthood, a...
Mohammed, Jaaved Arora, Neha Matthews, Harold S Hansen, Karissa Bader, Maram Walsh, Susan Shaffer, John R Weinberg, Seth M Swigut, Tomek Claes, Peter
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Published in
eLife
Genome-wide association studies (GWAS) identified thousands of genetic variants linked to phenotypic traits and disease risk. However, mechanistic understanding of how GWAS variants influence complex morphological traits and can, in certain cases, simultaneously confer normal-range phenotypic variation and disease predisposition, is still largely l...
Bryan, Nikaela W Ali, Aamir Niedzialkowska, Ewa Mayne, Leland Stukenberg, P Todd Black, Ben E
Published in
eLife
The physical basis of phase separation is thought to consist of the same types of bonds that specify conventional macromolecular interactions yet is unsatisfyingly often referred to as 'fuzzy'. Gaining clarity on the biogenesis of membraneless cellular compartments is one of the most demanding challenges in biology. Here, we focus on the chromosome...
