Branco, Joana Martins-Cruz, Cláudia Rodrigues, Lisa Silva, Raquel M. Araújo-Gomes, Nuno Gonçalves, Teresa Miranda, Isabel M. Rodrigues, Acácio G.
Published in
Virulence
Candida parapsilosis is an emergent opportunistic yeast among hospital settings that affects mainly neonates and immunocompromised patients. Its most remarkable virulence traits are the ability to adhere to prosthetic materials, as well as the formation of biofilm on abiotic surfaces. The Ndt80 transcription factor was identified as one of the regu...
Rom, Joseph S. Beenken, Karen E. Ramirez, Aura M. Walker, Christopher M. Echols, Ethan J. Smeltzer, Mark S.
Published in
Virulence
Using the USA300, methicillin-resistant Staphylococcus aureus strain LAC, we previously examined the impact of regulatory mutations implicated in biofilm formation on protease production and virulence in a murine sepsis model. Here we examined the impact of these mutations in the USA200, methicillin-sensitive strain UAMS-1. Mutation of agr, mgrA, r...
Hou, Wei Kang, Wenjie Li, Yangyang Shan, Yanke Wang, Shouyu Liu, Fei
Published in
Virulence
It is now clear that the intercellular transport on microtubules by dynein and kinesin-1 motors has an important role in the replication and spread of many viruses. Porcine epidemic diarrhea virus (PEDV) is an enveloped, single-stranded RNA virus of the Coronavirus family, which can infect swine of all ages and cause severe economic losses in the s...
Gischke, Marcel Bagato, Ola Breithaupt, Angele Scheibner, David Blaurock, Claudia Vallbracht, Melina Karger, Axel Crossley, Beate Veits, Jutta Böttcher-Friebertshäuser, Eva
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Published in
Virulence
To date, only low pathogenic (LP) H5 and H7 avian influenza viruses (AIV) have been observed to naturally shift to a highly pathogenic (HP) phenotype after mutation of the monobasic hemagglutinin (HA) cleavage site (HACS) to polybasic motifs. The LPAIV monobasic HACS is activated by tissue-restricted trypsin-like enzymes, while the HPAIV polybasic ...
Beata, Sobieszczańska Michał, Turniak Mateusz, Olbromski Urszula, Walczuk Choroszy, Marcin Andrzej, Tukiendorf Piotr, Dzięgiel
Published in
Virulence
Norepinephrine (NE), the stress hormone, stimulates many bacterial species’ growth and virulence, including Escherichia coli . However, the hormone’s impact on the adherent-invasive E. coli (AIEC) implicated in Crohn’s disease is poorly understood. In the study, we have investigated the effect of NE on the interaction of six AIEC strains isolated f...
Bernal-Martínez, L Gonçalves, SM de Andres, B Cunha, C Gonzalez Jimenez, I Lagrou, K Mellado, E Gaspar, ML Maertens, JA Carvalho, A
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Published in
Virulence
Pattern recognition receptors (PRRs) are responsible for Aspergillus fumigatus recognition by innate immunity and its subsequent immune signaling. The triggering receptor expressed on myeloid cells 1 (TREM1) is a recently characterized pro-inflammatory receptor constitutively expressed on the surface of neutrophils and macrophages. A soluble form (...
Dai, Ke Yang, Zhen Ma, Xiaoyu Chang, Yung-Fu Cao, Sanjie Zhao, Qin Huang, Xiaobo Wu, Rui Huang, Yong Xia, Jing
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Virulence
Polyamines are small, polycationic molecules with a hydrocarbon backbone and multiple amino groups required for optimal cell growth. The potD gene, belonging to the ABC (ATP-binding cassette) transport system potABCD , encodes the bacterial substrate-binding subunit of the polyamine transport system, playing a pivotal role in bacterial metabolism a...
Cheung, Gordon Y. C. Bae, Justin S. Otto, Michael
Published in
Virulence
Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of S. aureus infections is complicated by antibiotic resistance and a working vaccine is...
Hou, Xiaoyue Han, Lu An, Baoju Cai, Jun
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Virulence
Vip3Aa is an insecticidal protein that can effectively control certain lepidopteran pests and has been used widely in biological control. However, the mechanism of action of Vip3Aa is unclear. In the present study, we showed that Vip3Aa could cause autophagy in Sf9 cells, which was confirmed by the increased numbers of GFP-Atg8 puncta, the appearan...
Wang, Guanbo Glaser, Lena Scott, Nichollas E. Fathy Mohamed, Yasmine Ingram, Rebecca Laroucau, Karine Valvano, Miguel A.
Published in
Virulence
We recently described a protein O -glycosylation pathway conserved in all species of the Burkholderia genus that results in the synthesis and incorporation of a trisaccharide glycan to membrane-exported proteins. Here, we exploited this system to construct and evaluate a diagnostic tool for glanders. Burkholderia mallei , the causative agent of gla...