Hua, Mingxi Liu, Jingyuan Du, Pengcheng Liu, Xinzhe Li, Min Wang, Huizhu Chen, Chen Xu, Xinmin Jiang, Yu Wang, Yajie
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Published in
Virulence
Acinetobacter baumannii has become a major healthcare threat that causes nosocomial infections, especially in critically ill patients. The spread of carbapenem resistant A. baumannii (CRAB) strains has long been a clinical concern. It is important to study the epidemiology and virulence characteristics of different CRAB isolates in order to tailor ...
De Maio, Flavio Berisio, Rita Manganelli, Riccardo Delogu, Giovanni
Published in
Virulence
To the PE_PGRS protein subfamily belongs a group of surface-exposed mycobacterial antigens that in Mycobacterium tuberculosis (Mtb) H37Rv accounts to more than 65 genes, 51 of which are thought to express a functional protein. PE_PGRS proteins share a conserved structural architecture with three main domains: the N-terminal PE domain; the PGRS doma...
Chen, Jiaxin Han, Tao Huang, Mao Yang, Yi Shang, Futai Zheng, Yishan Zhao, Wenjing Luo, Liang Han, Xudong Lin, Aihua
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Published in
Virulence
Asymptomatic SARS-CoV-2-infected individuals are thought to play major roles in virus transmission. This study aimed to analyze the characteristics of asymptomatic carriers with COVID-19 to control the spread of the virus. We retrospectively investigated the clinical characteristics of 648 consecutive subjects who were enrolled in the study and wer...
Abdissa, Ketema Ruangkiattikul, Nanthapon Ahrend, Wiebke Nerlich, Andreas Beineke, Andreas Laarmann, Kristin Janze, Nina Lobermeyer, Ulrike Suwandi, Abdulhadi Falk, Christine
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Published in
Virulence
Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease (JD), an incurable chronic intestinal bowel disease in ruminants. JD occurs worldwide and causes enormous economic burden in dairy industry. Research on JD pathobiology is hampered by its complexity which cannot completely be mimicked by small animal models. As a model the...
Vanaporn, Muthita Titball, Richard W
Published in
Virulence
Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage, which plays both structural and functional roles in bacteria. Trehalose can be synthesized and degraded by several pathways, and induction of trehalose biosynthesis is typically associated with exposure to abiotic stress. The ability of trehalose to protect again...
Huang, Xiao-Wen Xu, Mei-Nian Zheng, Huan-Xin Wang, Meng-Lei Li, Li Zeng, Kang Li, De-Dong
Published in
Virulence
Commensal fungi are an important part of human microbial community, among which Candida albicans and Candida glabrata are two common opportunistic pathogens. Unlike the high pathogenicity of C. albicans, C. glabrata is reported to show low pathogenicity to the host. Here, by using a Galleria mellonella infection model, we were able to confirm the m...
Leal Zimmer, Fernanda M A Paes, Jéssica Andrade Zaha, Arnaldo Ferreira, Henrique Bunselmeyer
Published in
Virulence
Mycoplasma hyopneumoniae: is the etiological agent of porcine enzootic pneumonia (EP), a disease that impacts the swine industry worldwide. Pathogen-induced damage, as well as the elicited host-response, contribute to disease. Here, we provide an overview of EP epidemiology, control and prevention, and a more in-depth review of M. hyopneumoniae pat...
Aquaro, Stefano Borrajo, Ana Pellegrino, Michele Svicher, Valentina
Published in
Virulence
Ongoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of extinguishing the virus from the long-lived cellular reservoir, including monocyte-derived macrophage...
Ramirez, Aura M Beenken, Karen E Byrum, Stephanie D Tackett, Alan J Shaw, Lindsey N Gimza, Brittney D Smeltzer, Mark S
Published in
Virulence
Using DNA affinity chromatography we demonstrate that the S. aureus regulatory proteins MgrA, Rot, SarA, and SarS bind DNA baits derived from the promoter regions associated with the genes encoding aureolysin, ScpAB, SspABC, and SplA-F. Three of four baits also bound SarR and SarZ, the exception in both cases being the ScpAB-associated bait. Using ...
Yang, Man-Jun Xu, Di Yang, Dai-Xiao Li, Lu Peng, Xuan-Xian Chen, Zhuang-Gui Li, Hui
Published in
Virulence
Development of low-cost and eco-friendly approaches to fight bacterial pathogens is especially needed in aquaculture. We previously showed that exogenous malate reprograms zebrafish's metabolome to potentiate zebrafish survival against Vibrio alginolyticus infection. However, the underlying mechanism is unknown. Here, we use GC-MS based metabolomic...
