Bogaerts, Joep M A Steenbeek, Miranda P van Bommel, Majke H D Bulten, Johan van der Laak, Jeroen A W M de Hullu, Joanne A Simons, Michiel
Published in
Virchows Archiv : an international journal of pathology
Our understanding of the oncogenesis of high-grade serous cancer of the ovary and its precursor lesions, such as serous tubal intraepithelial carcinoma (STIC), has significantly increased over the last decades. Adequate and reproducible diagnosis of these precursor lesions is important. Diagnosing STIC can have prognostic consequences and is an abs...
Dorofte, Luiza Grélaud, Diane Fiorentino, Michelangelo Giunchi, Francesca Ricci, Costantino Franceschini, Tania Riefolo, Mattia Davidsson, Sabina Carlsson, Jessica Lillsunde Larsson, Gabriella
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Published in
Virchows Archiv : an international journal of pathology
Differentiation between penile squamous cell carcinoma patients who can benefit from limited organ-sparing surgery and those at significant risk of lymph node metastasis is based on histopathological prognostic factors including histological grade and tumor histological subtype. We examined levels of interobserver and intraobserver agreement in ass...
Machado, Isidro Charville, Gregory W Yoshida, Akihiko Navarro, Samuel Righi, Alberto Gambarotti, Marco Scotlandi, Katia López-Guerrero, José A Llombart-Bosch, Antonio
Published in
Virchows Archiv : an international journal of pathology
Ewing sarcoma (ES) is an aggressive neoplasm with variable morphology. It has no specific immunoprofile or molecular signature. Neither CD99, NKX2.2 nor PAX7 immunoreactivity alone is completely specific, although diagnostic specificity improves when combined. The purpose of the present study was to investigate the immunohistochemical (IHC) express...
Angerilli, Valentina Galuppini, Francesca Pennelli, Gianmaria Fanelli, Giuseppe Nicolo' d'Amore, Emanuele S G Michelotto, Mauro Pilati, Pierluigi Spolverato, Gaya Pucciarelli, Salvatore Scarpa, Marco
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Published in
Virchows Archiv : an international journal of pathology
Epstein-Barr virus (EBV) infection characterizes a portion of gastric adenocarcinomas. However, since there is lack of evidence of EBV presence in pre-neoplastic lesions of gastric mucosa, the etiologic role of EBV in gastric carcinogenesis is still debated. We report an unusual case of an EBV-associated foveolar gastric dysplasia associated with a...
Adachi, Kai Sakurai, Yasutaka Ichinoe, Masaaki Tadehara, Masayoshi Tamaki, Akihiro Kesen, Yurika Kato, Takuya Mii, Shinji Enomoto, Atsushi Takahashi, Masahide
...
Published in
Virchows Archiv : an international journal of pathology
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, whose expression is upregulated in some types of malignant tumors. High levels of CD109 in tumor cells have been reported to correlate with poor prognosis; however, significance of CD109 stromal expression in human malignancy has not been elucidated. In this study, we investigated the t...
Yamada, Yosuke Sugimoto, Akihiko Hoki, Masahito Yoshizawa, Akihiko Hamaji, Masatsugu Date, Hiroshi Haga, Hironori Marx, Alexander
Published in
Virchows Archiv : an international journal of pathology
The thymic medulla comprises various cell types, including tuft cells that are involved in innate immunity. We recently reported that in Western cohorts of patients, most thymic squamous cell carcinomas (TSQCCs), in contrast to thymomas, exhibit strong and extensive expression of tuft cell markers, including the tuft cell master regulator, POU2F3. ...
Rosen, Yale Garcia, Pascual Meseguer Navale, Pooja
Published in
Virchows Archiv : an international journal of pathology
The objectives are to precisely identify the cells that incite the formation of lesions that are generally known as "pulse granuloma" or "hyaline ring granuloma" that occur mostly in the oral cavity, in the lungs, in and around the gastrointestinal tract, and other sites, and to suggest an alternative name for these lesions that accurately reflects...
Nogueira, Rodrigo Justi Alves, Thales Müller Silvério Louzada, Mário Jefferson Quirino Camilo-Júnior, Deolino João Xavier-Júnior, José Cândido Caldeira
Published in
Virchows Archiv : an international journal of pathology
Zito Marino, Federica De Cristofaro, Tiziana Varriale, Massimo Zannini, Giuseppa Ronchi, Andrea La Mantia, Elvira Campobasso, Carlo Pietro De Micco, Francesco Mascolo, Pasquale Municinò, Maurizio
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Published in
Virchows Archiv : an international journal of pathology
Post-mortem examination plays a pivotal role in understanding the pathobiology of the SARS-CoV-2; thus, the optimization of virus detection on the post-mortem formalin-fixed paraffin-embedded (FFPE) tissue is needed. Different techniques are available for the identification of the SARS-CoV-2, including reverse transcription polymerase chain reactio...
Veloza, Luis Tsai, Chun-Yi Bisig, Bettina Pantet, Olivier Alberio, Lorenzo Sempoux, Christine Cavassini, Matthias de Leval, Laurence
Published in
Virchows Archiv : an international journal of pathology
Intravascular large B-cell lymphoma is a rare and aggressive EBV-negative large B-cell lymphoma with a dismal outcome. Here, we describe the case of a 76-year-old HIV-positive patient with an acute presentation of systemic symptoms and rapidly fatal outcome. Autopsy revealed a disseminated large B-cell lymphoma with an intravascular distribution in...
